Technology Process of (2R,3R,4R,5S,6R)-6-(hydroxymethyl)-3-(phenylamino)tetrahydro-2H-pyran-2,4,5-triol
There total 6 articles about (2R,3R,4R,5S,6R)-6-(hydroxymethyl)-3-(phenylamino)tetrahydro-2H-pyran-2,4,5-triol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen; trichloroacetic acid;
In
methanol; ethyl acetate;
at 40 ℃;
for 40h;
Schlenk technique;
Inert atmosphere;
DOI:10.1016/j.tetlet.2012.10.069
- Guidance literature:
-
Multi-step reaction with 2 steps
1: copper(l) iodide; caesium carbonate; 2-acetylcyclohexanone / N,N-dimethyl-formamide / 130 °C / Schlenk technique; Inert atmosphere; Sealed tube
2: palladium 10% on activated carbon; trichloroacetic acid; hydrogen / methanol; ethyl acetate / 40 h / 40 °C / Schlenk technique; Inert atmosphere
With
copper(l) iodide; 2-acetylcyclohexanone; palladium 10% on activated carbon; hydrogen; caesium carbonate; trichloroacetic acid;
In
methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2012.10.069
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: copper diacetate / dichloromethane; acetonitrile / 0.17 h / 20 °C / Molecular sieve
1.2: 24 h / 65 °C / Molecular sieve
2.1: hydrogen; palladium 10% on activated carbon; trichloroacetic acid / methanol; ethyl acetate / 40 h / 40 °C
With
palladium 10% on activated carbon; hydrogen; copper diacetate; trichloroacetic acid;
In
methanol; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1080/07328303.2013.816851
