N-[(R)-1-Phenylpropyl]-2-phenyl-3-hydroxyquinoline-4-carboxamide

Base Information

Chemical Name:N-[(R)-1-Phenylpropyl]-2-phenyl-3-hydroxyquinoline-4-carboxamide
CAS No.:174636-33-0
Molecular Formula:C₂₅H₂₂N₂O₂
Molecular Weight:382.462
Hs Code.:
DSSTox Substance ID:DTXSID101169464
Nikkaji Number:J1.091.878B
Pharos Ligand ID:WM3A3TPP6C5H
ChEMBL ID:CHEMBL430118

Synonyms:CHEMBL430118;SCHEMBL6449764;DTXSID101169464;BDBM50074791;3-Hydroxy-2-phenyl-N-[(1R)-1-phenylpropyl]-4-quinolinecarboxamide;N-[(R)-1-Phenylpropyl]-2-phenyl-3-hydroxyquinoline-4-carboxamide;3-Hydroxy-2-phenyl-quinoline-4-carboxylic acid ((R)-1-phenyl-propyl)-amide;174636-33-0

Suppliers and Price of N-[(R)-1-Phenylpropyl]-2-phenyl-3-hydroxyquinoline-4-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of N-[(R)-1-Phenylpropyl]-2-phenyl-3-hydroxyquinoline-4-carboxamide

Chemical Property:

XLogP3:5.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:382.168127949
Heavy Atom Count:29
Complexity:527

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(C1=CC=CC=C1)NC(=O)C2=C(C(=NC3=CC=CC=C32)C4=CC=CC=C4)O
Isomeric SMILES:CC[C@H](C1=CC=CC=C1)NC(=O)C2=C(C(=NC3=CC=CC=C32)C4=CC=CC=C4)O

Technology Process of N-[(R)-1-Phenylpropyl]-2-phenyl-3-hydroxyquinoline-4-carboxamide

There total 6 articles about N-[(R)-1-Phenylpropyl]-2-phenyl-3-hydroxyquinoline-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 485-89-2
oxycinchophen

: 2941-20-0,3082-64-2,3789-59-1,35600-74-9
1-phenylpropylamine

: 2387-23-7
1,3-Dicyclohexylurea

: 174636-33-0,174636-26-1
(S)-(-)-N-(α-ethylbenzyl)-3-hydroxy-2-phenyl-4-quinoline carboxamide

Guidance literature:: oxycinchophen; 1-phenylpropylamine; With 1-hydroxybenzotriazole; In tetrahydrofuran; dichloromethane; acetonitrile; at 20 ℃; for 0.666667h;

With dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; acetonitrile; at 20 ℃;

With water; at 20 ℃; for 0.5h;

Reference yield:

: 4079-52-1
methoxymethyl phenyl ketone

: 174636-33-0,174636-26-1
(S)-(-)-N-(α-ethylbenzyl)-3-hydroxy-2-phenyl-4-quinoline carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: aq. KOH / ethanol / 80 °C

2: 95 percent / 57 percent HI / 3 h / Heating

3: (COCl)2 / CH₂Cl₂ / 5 - 20 °C

4: K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

With potassium hydroxide; oxalyl dichloride; hydrogen iodide; potassium carbonate; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980633c

Reference yield:

: 485-89-2
oxycinchophen

: 174636-33-0,174636-26-1
(S)-(-)-N-(α-ethylbenzyl)-3-hydroxy-2-phenyl-4-quinoline carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: (COCl)2 / CH₂Cl₂ / 5 - 20 °C

2: K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

With oxalyl dichloride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980633c