6-Azacytidine

Base Information

Chemical Name:6-Azacytidine
CAS No.:3131-60-0
Molecular Formula:C₈H₁₂N₄O₅
Molecular Weight:244.207
Hs Code.:
European Community (EC) Number:636-538-3
UNII:YD42UEH51C
DSSTox Substance ID:DTXSID4020117
Nikkaji Number:J12.965H
ChEMBL ID:CHEMBL1334069
Mol file:3131-60-0.mol

Synonyms:6-azacytidine

Suppliers and Price of 6-Azacytidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biosynth Carbosynth
6-Azacytidine
5 mg
$ 400.00

Biosynth Carbosynth
6-Azacytidine
2 mg
$ 180.00

Biosynth Carbosynth
6-Azacytidine
1 mg
$ 100.00

American Custom Chemicals Corporation
6-AZACYTIDINE 95.00%
5MG
$ 500.96

Total 10 raw suppliers

Chemical Property of 6-Azacytidine

Chemical Property:

Appearance/Colour:white crystalline powder
Vapor Pressure:1.18E-13mmHg at 25°C
Melting Point:215 °C
Refractive Index:1.6590 (estimate)
Boiling Point:534.5 °C at 760 mmHg
PKA:13.44±0.70(Predicted)
Flash Point:277 °C
PSA：143.72000
Density:2.08 g/cm³
LogP:-2.58680
XLogP3:-2.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:244.08076950
Heavy Atom Count:17
Complexity:384

Purity/Quality:

97% ^*data from raw suppliers

6-Azacytidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=NN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O
Isomeric SMILES:C1=NN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O

Technology Process of 6-Azacytidine

There total 10 articles about 6-Azacytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: N2-(2',3',5'-tri-O-acetyl)-β-D-ribofuranosyl-5-methylmercapto-1,2,4-triazin-3(2H)-one

: 14528-15-5,3131-60-0
6-azacytidine

Guidance literature:: With ammonium hydroxide; In ethanol; at 20 ℃;
DOI:10.1080/15257770.2015.1034363

Reference yield:

: 20757-62-4
2',3',5'-tri-O-acetyl-6-azacytidine

: 14528-15-5,3131-60-0
6-azacytidine

Guidance literature:: With alkali medium;
DOI:10.1081/NCN-100002508

Reference yield:

: 257297-86-2
Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(3-oxo-5-[1,2,4]triazol-1-yl-3H-[1,2,4]triazin-2-yl)-tetrahydro-furan-3-yl ester

: 14528-15-5,3131-60-0
6-azacytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 226 mg / NH₄Cl; DBU / pyridine / 24 h / 20 °C

2: NH₃ / methanol / 24 h / 20 °C

With ammonia; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In pyridine; methanol;
DOI:10.1021/ja001918t