3-Benzyl-2,2-difluoro-3-hydroxy-4-phenyl-butyric acid ethyl ester

Base Information

• Chemical Name: 3-Benzyl-2,2-difluoro-3-hydroxy-4-phenyl-butyric acid ethyl ester
• CAS No.: 168558-22-3
• Molecular Formula: C₁₉H₂₀F₂O₃
• Molecular Weight: 334.363
• Mol file: 168558-22-3.mol

Synonyms:3-Benzyl-2,2-difluoro-3-hydroxy-4-phenyl-butyric acid ethyl ester

Chemical Property of 3-Benzyl-2,2-difluoro-3-hydroxy-4-phenyl-butyric acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-Benzyl-2,2-difluoro-3-hydroxy-4-phenyl-butyric acid ethyl ester

There total 1 articles about 3-Benzyl-2,2-difluoro-3-hydroxy-4-phenyl-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Ethyl bromodifluoroacetate (667-27-6) + 1,3-Diphenylpropanone (102-04-5) → 3-Benzyl-2,2-difluoro-3-hydroxy-4-phenyl-butyric acid ethyl ester (168558-22-3)

Guidance literature:

With zinc; In tetrahydrofuran; Heating;

DOI:10.1021/jo00122a007

Reference yield: 97.0%

3-Benzyl-2,2-difluoro-3-hydroxy-4-phenyl-butyric acid ethyl ester (168558-22-3) → 3-Benzyl-2,2-difluoro-3-hydroxy-4-phenyl-butyric acid (168558-25-6)

Guidance literature:

With sodium hydroxide; for 18h; Ambient temperature;

DOI:10.1021/jo00122a007

Reference yield:

3-Benzyl-2,2-difluoro-3-hydroxy-4-phenyl-butyric acid ethyl ester (168558-22-3) → (2-(difluoromethylene)propane-1,3-diyl)dibenzene

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / aq. NaOH / Ambient temperature

2: 85 percent / PhSO₂Cl, pyridine / CHCl₃ / 20 h / 0 °C

3: 95 percent / 150 °C

With pyridine; sodium hydroxide; benzenesulfonyl chloride; In chloroform;

DOI:10.1016/S0022-1139(97)00134-6

upstream raw materials:

Ethyl bromodifluoroacetate

1,3-Diphenylpropanone

Downstream raw materials:

3-Benzyl-2,2-difluoro-3-hydroxy-4-phenyl-butyric acid

4,4-Dibenzyl-3,3-difluoro-2-oxetanone