3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]benzenesulfonamide

Base Information

Chemical Name:3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]benzenesulfonamide
CAS No.:1359026-93-9
Molecular Formula:C₂₁H₁₈F₃N₅O₃S
Molecular Weight:477.467
Hs Code.:

Synonyms:3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]benzenesulfonamide

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Chemical Property of 3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]benzenesulfonamide

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Technology Process of 3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]benzenesulfonamide

There total 7 articles about 3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1359029-69-8
1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-carboxylic acid

: 90000-88-7
N-hydroxy-3-sulfamoylbenzene carboximidamide

: 1359026-93-9
3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]benzenesulfonamide

Guidance literature:: 1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-carboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 30 ℃; for 2h; Inert atmosphere;

N-hydroxy-3-sulfamoylbenzene carboximidamide; In N,N-dimethyl-formamide; at 80 ℃; for 21h;

With acetic acid; for 7h; Reflux;

Reference yield:

: 1356997-87-9
4-iodo-1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

: 1359026-93-9
3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 65 °C

2.1: potassium hydroxide; ethanol / 3 h / Reflux

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 2 h / 30 °C / Inert atmosphere

3.2: 21 h / 80 °C

3.3: 7 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; potassium carbonate; 1,1'-carbonyldiimidazole; potassium hydroxide; In N,N-dimethyl-formamide;

Reference yield:

: 1356997-45-9
1-methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}-1H-pyrazole

: 1359026-93-9
3-[5-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

2.1: N-iodo-succinimide; trifluoroacetic acid / 1 h / 20 °C

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 65 °C

4.1: potassium hydroxide; ethanol / 3 h / Reflux

5.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 2 h / 30 °C / Inert atmosphere

5.2: 21 h / 80 °C

5.3: 7 h / Reflux

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; palladium 10% on activated carbon; hydrogen; potassium carbonate; 1,1'-carbonyldiimidazole; trifluoroacetic acid; potassium hydroxide; In methanol; N,N-dimethyl-formamide;