Technology Process of 4-(methoxycarbonyl)-6-methyl-5-(2-oxoethyl)-1,3-phenylene dibenzoate
There total 10 articles about 4-(methoxycarbonyl)-6-methyl-5-(2-oxoethyl)-1,3-phenylene dibenzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-allyl-4-(methoxycarbonyl)-6-methyl-1,3-phenylene dibenzoate;
With
ozone;
In
dichloromethane;
at -78 ℃;
for 0.166667h;
With
triphenylphosphine;
In
dichloromethane;
at -78 - 20 ℃;
DOI:10.1002/chem.201203149
- Guidance literature:
-
With
sodium periodate;
In
methanol;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/ja3057612
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: potassium carbonate / acetone / 20 °C / Molecular sieve
2.1: boron trichloride / dichloromethane; n-heptane / 1 h / -78 - 20 °C
3.1: trichlorophosphate / acetonitrile / 0 - 20 °C / Inert atmosphere
4.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; ethanol / 4 h / 20 °C
5.1: pyridine / dichloromethane / 0 - 20 °C
6.1: tetrakis(triphenylphosphine) palladium(0); lithium chloride / tetrahydrofuran / 7 h / Inert atmosphere; Reflux
7.1: boron tribromide / dichloromethane / -78 - 0 °C
8.1: pyridine; dmap / dichloromethane / 0 - 20 °C
9.1: ozone / dichloromethane / 0.17 h / -78 °C
9.2: -78 - 20 °C
With
pyridine; dmap; tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon; hydrogen; boron trichloride; boron tribromide; potassium carbonate; ozone; lithium chloride; trichlorophosphate;
In
tetrahydrofuran; ethanol; n-heptane; dichloromethane; ethyl acetate; acetone; acetonitrile;
3.1: |Vilsmeier-Haack Formylation / 6.1: |Stille Cross Coupling;
DOI:10.1002/chem.201203149
