2-(5-{2-[2-(5-{3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-2-hydroxy-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionyloxy]-1-methyl-pentyl}-tetrahydro-furan-2-yl)-propionic acid benzyl ester

Base Information

Chemical Name:2-(5-{2-[2-(5-{3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-2-hydroxy-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionyloxy]-1-methyl-pentyl}-tetrahydro-furan-2-yl)-propionic acid benzyl ester
CAS No.:870452-60-1
Molecular Formula:C₄₃H₇₁NO₈
Molecular Weight:730.039
Hs Code.:

2-(5-{2-[2-(5-{3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-2-hydroxy-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionyloxy]-1-methyl-pentyl}-tetrahydro-furan-2-yl)-propionic acid benzyl ester

Synonyms:2-(5-{2-[2-(5-{3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-2-hydroxy-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionyloxy]-1-methyl-pentyl}-tetrahydro-furan-2-yl)-propionic acid benzyl ester

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Chemical Property of 2-(5-{2-[2-(5-{3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-2-hydroxy-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionyloxy]-1-methyl-pentyl}-tetrahydro-furan-2-yl)-propionic acid benzyl ester

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Technology Process of 2-(5-{2-[2-(5-{3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-2-hydroxy-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionyloxy]-1-methyl-pentyl}-tetrahydro-furan-2-yl)-propionic acid benzyl ester

There total 6 articles about 2-(5-{2-[2-(5-{3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-2-hydroxy-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionyloxy]-1-methyl-pentyl}-tetrahydro-furan-2-yl)-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 870452-59-8
2-(5-{2-(tert-butyl-dimethyl-silanyloxy)-3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid 1-{1-[5-(1-benzyloxycarbonyl-ethyl)-tetrahydro-furan-2-yl]-ethyl}-butyl ester

: 870452-60-1
2-(5-{2-[2-(5-{3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-2-hydroxy-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionyloxy]-1-methyl-pentyl}-tetrahydro-furan-2-yl)-propionic acid benzyl ester

Guidance literature:: With hydrogen fluoride; In water; acetonitrile; at 20 ℃;
DOI:10.1002/anie.200501511

Reference yield:

: 4,6-dimethyl-1,1-dioxo-3-propyl-3,4,6,7,8,8a-hexahydro-1H-1λ⁶-benzo[c][1,2]oxathiin-7-ol

: 870452-60-1
2-(5-{2-[2-(5-{3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-2-hydroxy-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionyloxy]-1-methyl-pentyl}-tetrahydro-furan-2-yl)-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: ozone; NaHCO₃ / CH₂Cl₂ / -78 °C

1.2: 87 percent / acetic anhydride; pyridine / CH₂Cl₂ / Heating

2.1: 79 percent / BF₃*Et₂O / CH₂Cl₂ / 20 °C

3.1: 59 percent / H₂ / Raney Ni / ethanol / 20 °C / 37503 Torr

4.1: 93 percent / Bu₂SnO / 160 °C

5.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 0 - 20 °C

5.2: 88 percent / 4-(N,N-dimethylamino)pyridine / toluene / 20 °C

6.1: 95 percent / HF / acetonitrile; H₂O / 20 °C

With 2,4,6-trichlorobenzoyl chloride; boron trifluoride diethyl etherate; hydrogen fluoride; hydrogen; di(n-butyl)tin oxide; sodium hydrogencarbonate; ozone; triethylamine; nickel; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile; 5.1: Yamaguchi coupling;
DOI:10.1002/anie.200501511

Reference yield:

: 870452-53-2
(R)-2-((2R,6S,7S)-7-Methyl-4,4-dioxo-7a-phenylsulfanyl-6-propyl-hexahydro-1,5-dioxa-4λ⁶-thia-inden-2-yl)-propionic acid methyl ester

: 870452-60-1
2-(5-{2-[2-(5-{3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-2-hydroxy-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionyloxy]-1-methyl-pentyl}-tetrahydro-furan-2-yl)-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 59 percent / H₂ / Raney Ni / ethanol / 20 °C / 37503 Torr

2.1: 93 percent / Bu₂SnO / 160 °C

3.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 0 - 20 °C

3.2: 88 percent / 4-(N,N-dimethylamino)pyridine / toluene / 20 °C

4.1: 95 percent / HF / acetonitrile; H₂O / 20 °C

With 2,4,6-trichlorobenzoyl chloride; hydrogen fluoride; hydrogen; di(n-butyl)tin oxide; triethylamine; nickel; In tetrahydrofuran; ethanol; water; acetonitrile; 3.1: Yamaguchi coupling;
DOI:10.1002/anie.200501511