4-[(R)-1-(5-{5-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazin-2-yl}-[1,2,4]oxadiazol-3-yl)ethoxy]piperidine-1-carboxylic acid isopropyl ester

Base Information

• Chemical Name: 4-[(R)-1-(5-{5-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazin-2-yl}-[1,2,4]oxadiazol-3-yl)ethoxy]piperidine-1-carboxylic acid isopropyl ester
• CAS No.: 1245079-62-2
• Molecular Formula: C₃₂H₄₁F₂N₇O₆
• Molecular Weight: 657.718

Synonyms:4-[(R)-1-(5-{5-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazin-2-yl}-[1,2,4]oxadiazol-3-yl)ethoxy]piperidine-1-carboxylic acid isopropyl ester

Chemical Property of 4-[(R)-1-(5-{5-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazin-2-yl}-[1,2,4]oxadiazol-3-yl)ethoxy]piperidine-1-carboxylic acid isopropyl ester

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Technology Process of 4-[(R)-1-(5-{5-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazin-2-yl}-[1,2,4]oxadiazol-3-yl)ethoxy]piperidine-1-carboxylic acid isopropyl ester

There total 1 articles about 4-[(R)-1-(5-{5-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazin-2-yl}-[1,2,4]oxadiazol-3-yl)ethoxy]piperidine-1-carboxylic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(3R,4S)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester (1245079-22-4) + 4-{(R)-1-[5-(5-chloropyrazin-2-yl)-[1,2,4]oxadiazol-3-yl]ethoxy}-piperidine-1-carboxylic acid isopropyl ester (1245079-76-8) → 4-[(R)-1-(5-{5-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazin-2-yl}-[1,2,4]oxadiazol-3-yl)ethoxy]piperidine-1-carboxylic acid isopropyl ester (1245079-62-2)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tert-butyl alcohol; at 70 ℃; for 1h;

Reference yield:

4-[(R)-1-(5-{5-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazin-2-yl}-[1,2,4]oxadiazol-3-yl)ethoxy]piperidine-1-carboxylic acid isopropyl ester (1245079-62-2) → 4-[(R)-1-(5-{5-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazin-2-yl}-[1,2,4]oxadiazol-3-yl)ethoxy]piperidine-1-carboxylic acid isopropyl ester (1245077-82-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

upstream raw materials:

[(3R,4S)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

4-{(R)-1-[5-(5-chloropyrazin-2-yl)-[1,2,4]oxadiazol-3-yl]ethoxy}-piperidine-1-carboxylic acid isopropyl ester

Downstream raw materials:

4-[(R)-1-(5-{5-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazin-2-yl}-[1,2,4]oxadiazol-3-yl)ethoxy]piperidine-1-carboxylic acid isopropyl ester

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