4-(2-fluoro-5-trifluoromethylphenyl)-1-[2-(4-oxocyclohexyl)ethyl]piperazine

Base Information

Chemical Name:4-(2-fluoro-5-trifluoromethylphenyl)-1-[2-(4-oxocyclohexyl)ethyl]piperazine
CAS No.:1000044-40-5
Molecular Formula:C₁₉H₂₄F₄N₂O
Molecular Weight:372.406
Hs Code.:

Synonyms:4-(2-fluoro-5-trifluoromethylphenyl)-1-[2-(4-oxocyclohexyl)ethyl]piperazine

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Chemical Property of 4-(2-fluoro-5-trifluoromethylphenyl)-1-[2-(4-oxocyclohexyl)ethyl]piperazine

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Technology Process of 4-(2-fluoro-5-trifluoromethylphenyl)-1-[2-(4-oxocyclohexyl)ethyl]piperazine

There total 4 articles about 4-(2-fluoro-5-trifluoromethylphenyl)-1-[2-(4-oxocyclohexyl)ethyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 198640-16-3
4-(2-hydroxyethyl)cyclohexanone mesylate

: 321601-98-3
1-(2-fluoro-5-trifluoromethylphenyl)piperazine

: 1000044-40-5
4-(2-fluoro-5-trifluoromethylphenyl)-1-[2-(4-oxocyclohexyl)ethyl]piperazine

Guidance literature:: With potassium carbonate; In acetonitrile; Heating / reflux;

Reference yield:

: 501-94-0
p-hydroxyphenethyl alcohol

: 1000044-40-5
4-(2-fluoro-5-trifluoromethylphenyl)-1-[2-(4-oxocyclohexyl)ethyl]piperazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: borax; hydrogen / palladium 10% on activated carbon / isopropyl alcohol / 22 h / 80 °C / 7500.75 Torr

2.1: acetic acid / 0.58 h / 18 - 21 °C

2.2: 0.75 h

3.1: triethylamine / dichloromethane / 2 h / 20 °C

4.1: potassium carbonate / acetonitrile / Heating / reflux

With borax; hydrogen; potassium carbonate; acetic acid; triethylamine; palladium 10% on activated carbon; In dichloromethane; isopropyl alcohol; acetonitrile;

Reference yield:

: 32863-01-7
4-(2-hydroxyethyl)cyclohexan-1-one

: 1000044-40-5
4-(2-fluoro-5-trifluoromethylphenyl)-1-[2-(4-oxocyclohexyl)ethyl]piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h / 20 °C

2: potassium carbonate / acetonitrile / Heating / reflux

With potassium carbonate; triethylamine; In dichloromethane; acetonitrile;