N-[6-chloro-4-(4-fluoro-2-methoxyphenyl)pyridazin-3-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethyl benzamide

Base Information

Chemical Name:N-[6-chloro-4-(4-fluoro-2-methoxyphenyl)pyridazin-3-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethyl benzamide
CAS No.:1466573-98-7
Molecular Formula:C₂₁H₁₆ClF₄N₃O₄S
Molecular Weight:517.888
Hs Code.:

Synonyms:N-[6-chloro-4-(4-fluoro-2-methoxyphenyl)pyridazin-3-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethyl benzamide

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Chemical Property of N-[6-chloro-4-(4-fluoro-2-methoxyphenyl)pyridazin-3-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethyl benzamide

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Technology Process of N-[6-chloro-4-(4-fluoro-2-methoxyphenyl)pyridazin-3-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethyl benzamide

There total 3 articles about N-[6-chloro-4-(4-fluoro-2-methoxyphenyl)pyridazin-3-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethyl benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.3%

: 53985-43-6
3-methanesulfonyl-5-trifluoromethylbenzoic acid

: 1466574-37-7
N-[6-chloro-4-(4-fluoro-2-methoxyphenyl)pyridazin-3-yl]methylamine

: 1466573-98-7
N-[6-chloro-4-(4-fluoro-2-methoxyphenyl)pyridazin-3-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethyl benzamide

Guidance literature:: With 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 1395415-86-7
3-methanesulfonyl-5-trifluoromethylbenzoic acid methyl ester

: 1466573-98-7
N-[6-chloro-4-(4-fluoro-2-methoxyphenyl)pyridazin-3-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethyl benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide monohydrate / 1,4-dioxane / 2 h / 20 °C

2: 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 20 °C

With lithium hydroxide monohydrate; water; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;

Reference yield:

: 1215205-96-1
1-bromo-3-(methylsulfonyl)-5-(trifluoromethyl)benzene

: 1466573-98-7
N-[6-chloro-4-(4-fluoro-2-methoxyphenyl)pyridazin-3-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethyl benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / ethyl acetate / 20 h / 110 °C / 52505.3 Torr

2: water; lithium hydroxide monohydrate / 1,4-dioxane / 2 h / 20 °C

3: 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium hydroxide monohydrate; water; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; ethyl acetate;