1-{4-fluoro-1-(phenylsulfonyl)-5-[2-(trifluoromethyl)pyridin-3-yl]-1H-pyrrol-3-yl}-N-methylmethanamine hydrochloride

Base Information

Chemical Name:1-{4-fluoro-1-(phenylsulfonyl)-5-[2-(trifluoromethyl)pyridin-3-yl]-1H-pyrrol-3-yl}-N-methylmethanamine hydrochloride
CAS No.:1055305-14-0
Molecular Formula:C₁₈H₁₅F₄N₃O₂S*ClH
Molecular Weight:449.857
Hs Code.:

Synonyms:1-{4-fluoro-1-(phenylsulfonyl)-5-[2-(trifluoromethyl)pyridin-3-yl]-1H-pyrrol-3-yl}-N-methylmethanamine hydrochloride

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Chemical Property of 1-{4-fluoro-1-(phenylsulfonyl)-5-[2-(trifluoromethyl)pyridin-3-yl]-1H-pyrrol-3-yl}-N-methylmethanamine hydrochloride

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Technology Process of 1-{4-fluoro-1-(phenylsulfonyl)-5-[2-(trifluoromethyl)pyridin-3-yl]-1H-pyrrol-3-yl}-N-methylmethanamine hydrochloride

There total 9 articles about 1-{4-fluoro-1-(phenylsulfonyl)-5-[2-(trifluoromethyl)pyridin-3-yl]-1H-pyrrol-3-yl}-N-methylmethanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1055306-80-3
tert-butyl ({4-fluoro-1-(phenylsulfonyl)-5-[2-(trifluoromethyl)pyridin-3-yl]-1H-pyrrol-3-yl}methyl)methylcarbamate

: 1055305-14-0
1-{4-fluoro-1-(phenylsulfonyl)-5-[2-(trifluoromethyl)pyridin-3-yl]-1H-pyrrol-3-yl}-N-methylmethanamine hydrochloride

Guidance literature:: With hydrogenchloride; ethanol; In ethyl acetate; at 20 ℃; for 3h;

Reference yield:

: 1055306-63-2
tert-butyl (4RS)-4-(bromomethyl)-3,3-difluoro-2-oxopyrrolidine-1-carboxylate

: 1055305-14-0
1-{4-fluoro-1-(phenylsulfonyl)-5-[2-(trifluoromethyl)pyridin-3-yl]-1H-pyrrol-3-yl}-N-methylmethanamine hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1.25 h / 0 - 20 °C

2.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2.75 h / -78 °C

2.2: 2 h / -78 °C

3.1: hydrogenchloride; water; acetic acid / 2 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 18 h / 0 - 60 °C

4.2: 1 h / 0 °C

5.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

5.2: 0.5 h / 0 °C

6.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 1 h / 0 °C

6.2: 14 h / 0 - 80 °C

6.3: 48 h / 20 °C

7.1: hydrogenchloride; ethanol / ethyl acetate / 3 h / 20 °C

With 2,2,6,6-tetramethyl-piperidine; hydrogenchloride; n-butyllithium; ethanol; carbonochloridic acid 1-chloro-ethyl ester; water; sodium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; hexane; ethyl acetate;

Reference yield:

: 1055306-64-3
tert-butyl 3,3-difluoro-4-methylidene-2-oxopyrrolidine-1-carboxylate

: 1055305-14-0
1-{4-fluoro-1-(phenylsulfonyl)-5-[2-(trifluoromethyl)pyridin-3-yl]-1H-pyrrol-3-yl}-N-methylmethanamine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2.75 h / -78 °C

1.2: 2 h / -78 °C

2.1: hydrogenchloride; water; acetic acid / 2 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 18 h / 0 - 60 °C

3.2: 1 h / 0 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

4.2: 0.5 h / 0 °C

5.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 1 h / 0 °C

5.2: 14 h / 0 - 80 °C

5.3: 48 h / 20 °C

6.1: hydrogenchloride; ethanol / ethyl acetate / 3 h / 20 °C

With 2,2,6,6-tetramethyl-piperidine; hydrogenchloride; n-butyllithium; ethanol; carbonochloridic acid 1-chloro-ethyl ester; water; sodium hydride; acetic acid; In tetrahydrofuran; hexane; ethyl acetate;