2-chloro-4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)phenol

Base Information

Chemical Name:2-chloro-4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)phenol
CAS No.:847064-33-9
Molecular Formula:C₂₅H₂₁ClF₃NO₂
Molecular Weight:459.895
Hs Code.:

Synonyms:2-chloro-4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)phenol

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Chemical Property of 2-chloro-4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)phenol

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Technology Process of 2-chloro-4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)phenol

There total 1 articles about 2-chloro-4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 844901-56-0
3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indole

: 33697-81-3
(3-chloro-4-hydroxy-phenyl)-acetic acid

: 847064-33-9
2-chloro-4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)phenol

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,2-dichloro-ethane; at 0 - 20 ℃;

Reference yield: 93.0%

: 847064-33-9
2-chloro-4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)phenol

: 5292-43-3
bromoacetic acid tert-butyl ester

: tert-butyl[2-chloro-4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)phenoxy] acetate

Guidance literature:: 2-chloro-4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)phenol; With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1h;

bromoacetic acid tert-butyl ester; In DMF (N,N-dimethyl-formamide); at 20 - 50 ℃;