2,3-Dihydro-1-[2-(phenylmethoxy)ethyl]-1H-isoindole

Base Information

Chemical Name:2,3-Dihydro-1-[2-(phenylmethoxy)ethyl]-1H-isoindole
CAS No.:127797-18-6
Molecular Formula:C₁₇H₁₉NO
Molecular Weight:253.344
Hs Code.:
DSSTox Substance ID:DTXSID301223905

Synonyms:2,3-Dihydro-1-[2-(phenylmethoxy)ethyl]-1H-isoindole;DTXSID301223905;127797-18-6

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,3-Dihydro-1-[2-(phenylmethoxy)ethyl]-1H-isoindole

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:253.146664230
Heavy Atom Count:19
Complexity:262

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C2=CC=CC=C2C(N1)CCOCC3=CC=CC=C3

Technology Process of 2,3-Dihydro-1-[2-(phenylmethoxy)ethyl]-1H-isoindole

There total 3 articles about 2,3-Dihydro-1-[2-(phenylmethoxy)ethyl]-1H-isoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 127797-26-6
[1-[1-(2-Benzyloxy-ethyl)-1,3-dihydro-isoindol-2-yl]-meth-(E)-ylidene]-tert-butyl-amine

: 127797-18-6
1-(2-Benzyloxy-ethyl)-2,3-dihydro-1H-isoindole

Guidance literature:: With acetic acid; hydrazine; In ethanol; water; at 60 ℃;
DOI:10.1016/S0040-4039(00)94570-2

Reference yield:

: 496-12-8
isoindoline

: 127797-18-6
1-(2-Benzyloxy-ethyl)-2,3-dihydro-1H-isoindole

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / ammonium sulphate / toluene / 4.5 h / Heating

2: 1) sec-buthyllithium / tetrahydrofuran / 1) -78 deg C, 0.25 h, 2) -20 deg C, 0.5-1 h

3: 55 percent / hydrazine, acetic acid / ethanol; H₂O / 60 °C

With ammonium sulfate; sec.-butyllithium; acetic acid; hydrazine; In tetrahydrofuran; ethanol; water; toluene;
DOI:10.1016/S0040-4039(00)94570-2

Reference yield:

: 127797-30-2
N-(tert-butyliminomethyl)isoindoline

: 127797-18-6
1-(2-Benzyloxy-ethyl)-2,3-dihydro-1H-isoindole

Guidance literature:: Multi-step reaction with 2 steps

1: 1) sec-buthyllithium / tetrahydrofuran / 1) -78 deg C, 0.25 h, 2) -20 deg C, 0.5-1 h

2: 55 percent / hydrazine, acetic acid / ethanol; H₂O / 60 °C

With sec.-butyllithium; acetic acid; hydrazine; In tetrahydrofuran; ethanol; water;
DOI:10.1016/S0040-4039(00)94570-2