trifluoroacetohydrazide N-<2-(phenylethynyl)phenyl>imide

Base Information

• Chemical Name: trifluoroacetohydrazide N-<2-(phenylethynyl)phenyl>imide
• CAS No.: 167287-91-4
• Molecular Formula: C₁₆H₁₂F₃N₃
• Molecular Weight: 303.287
• Mol file: 167287-91-4.mol

Synonyms:trifluoroacetohydrazide N-<2-(phenylethynyl)phenyl>imide

Chemical Property of trifluoroacetohydrazide N-<2-(phenylethynyl)phenyl>imide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of trifluoroacetohydrazide N-<2-(phenylethynyl)phenyl>imide

There total 2 articles about trifluoroacetohydrazide N-<2-(phenylethynyl)phenyl>imide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2,2,2-Trifluoro-N-(2-phenylethynyl-phenyl)-acetimidoyl chloride → trifluoroacetohydrazide N-<2-(phenylethynyl)phenyl>imide (167287-91-4)

Guidance literature:

With hydrazine hydrate; In water; acetonitrile;

DOI:10.1246/bcsj.68.1497

Reference yield:

2-phenylethynylaniline (13141-38-3) → trifluoroacetohydrazide N-<2-(phenylethynyl)phenyl>imide (167287-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) PPh₃, Et₃N / 1.) CCl₄, 0 deg C, 10 min, 2.) CCl₄, 70 deg C, 5 h

2: 87 percent / NH₂NH₂*H₂O / acetonitrile; H₂O

With hydrazine hydrate; triethylamine; triphenylphosphine; In water; acetonitrile;

DOI:10.1246/bcsj.68.1497

Reference yield:

trifluoroacetohydrazide N-<2-(phenylethynyl)phenyl>imide (167287-91-4) → 3-(α-phenylthiobenzyl)-2-trifluoromethylindole

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / acetonitrile

2: Pb(OAc)4 / CH₂Cl₂ / 0.5 h

3: 72 percent / toluene / 0.05 h / 100 °C

With lead(IV) acetate; triethylamine; In dichloromethane; toluene; acetonitrile;

DOI:10.1246/bcsj.68.1497

upstream raw materials:

2-phenylethynylaniline

Downstream raw materials:

C₃₅H₂₆F₃N₃