Metolazone

Base Information

• Chemical Name: Metolazone
• CAS No.: 17560-51-9
• Molecular Formula: C₁₆H₁₆ClN₃O₃S
• Molecular Weight: 365.84
• Hs Code.: DERIVATION
• European Community (EC) Number: 241-539-3
• NSC Number: 759581
• UNII: NM7V2Y3G0U,TZ7V40X7VX,NN9U607695
• DSSTox Substance ID: DTXSID6045167
• Nikkaji Number: J3.450I
• Wikipedia: Metolazone
• Wikidata: Q1169561
• NCI Thesaurus Code: C650
• RXCUI: 6916
• Pharos Ligand ID: RBWTQRT26A9C
• Metabolomics Workbench ID: 42864
• ChEMBL ID: CHEMBL878
• Mol file: 17560-51-9.mol

Synonyms:Diulo;Metolazone;Microx;Mykrox;SR 720 22;SR-720-22;SR72022;Zaroxolyn

Chemical Property of Metolazone

Chemical Property:

• Appearance/Colour: Crystalline solid
• Vapor Pressure: 7.82E-15mmHg at 25°C
• Melting Point: 252-254°C
• Refractive Index: 1.624
• Boiling Point: 613.6 °C at 760 mmHg
• PKA: pKa 9.7 (Uncertain)
• Flash Point: 324.9 °C
• PSA: 100.88000
• Density: 1.4 g/cm³
• LogP: 4.69820
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO: >5mg/mL
• Water Solubility.: 60.3mg/L(25 oC)
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 365.0600902
• Heavy Atom Count: 24
• Complexity: 594

Purity/Quality:

99.0% ^*data from raw suppliers

Metolazone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1NC2=CC(=C(C=C2C(=O)N1C3=CC=CC=C3C)S(=O)(=O)N)Cl
• Recent ClinicalTrials: DAPAgliflozin Versus Thiazide Diuretic in Patients With Heart Failure and Diuretic RESISTance
• Recent EU Clinical Trials: DAPA-RESIST - Sodium glucose cotransporter-2 inhibitor DAPAgliflozin versus thiazide diuretic in patients with heart failure and diuretic RESISTance: a multi-centre, open-label, randomised controlled clinical trial
• Description: Metolazone (Item No. 26304) is an analytical reference standard categorized as a diuretic. It has been detected as an adverse analytical finding (AAF) during anti-doping testing. This product is intended for use in analytical forensic applications. This product is also available as a general research tool .
• Uses: Metolazone acts on the distal tubules, thus increasing excretion of water and sodium, potassium, and chloride ions. It is used for treating edema caused by cardiac insufficiency and adrenal irregularities, including nephrotic syndrome. A diruetic. An antihypertensive diuretic, antihypertensive
• Therapeutic Function: Diuretic

Technology Process of Metolazone

There total 1 articles about Metolazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ metolazone (17560-51-9,56436-31-8,56436-32-9)

Guidance literature:

DOI:10.1021/jm00299a022

Refernces

• 1、 -. "Tetrahydro-halo-sulfamyl quinazolinones". . . Retrieved 2014/02/11.