4-(tert-butyldimethylsilanyloxy)-4-(4-fluorophenyl)butan-1-ol

Base Information

• Chemical Name: 4-(tert-butyldimethylsilanyloxy)-4-(4-fluorophenyl)butan-1-ol
• CAS No.: 869588-30-7
• Molecular Formula: C₁₆H₂₇FO₂Si
• Molecular Weight: 298.473
• Mol file: 869588-30-7.mol

Synonyms:4-(tert-butyldimethylsilanyloxy)-4-(4-fluorophenyl)butan-1-ol

Chemical Property of 4-(tert-butyldimethylsilanyloxy)-4-(4-fluorophenyl)butan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(tert-butyldimethylsilanyloxy)-4-(4-fluorophenyl)butan-1-ol

There total 4 articles about 4-(tert-butyldimethylsilanyloxy)-4-(4-fluorophenyl)butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[4-benzyloxy-1-(4-fluoro-phenyl)-butoxy]-tert-butyl-dimethyl-silane → 4-(tert-butyldimethylsilanyloxy)-4-(4-fluorophenyl)butan-1-ol (869588-30-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 2.25h;

DOI:10.1039/b510100j

Reference yield:

4-benzyloxy-1-(4-fluorophenyl)but-2-yn-1-ol (869588-29-4) → 4-(tert-butyldimethylsilanyloxy)-4-(4-fluorophenyl)butan-1-ol (869588-30-7)

Guidance literature:

Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / 3.5 h

2: Na₂CO₃; H₂ / Pd/C / ethanol / 19 h

3: 3.643 g / H₂ / Pd/C / ethanol / 2.25 h

With 1H-imidazole; hydrogen; sodium carbonate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1039/b510100j

Reference yield:

[4-benzyloxy-1-(4-fluoro-phenyl)-but-2-ynyloxy]-tert-butyl-dimethyl-silane → 4-(tert-butyldimethylsilanyloxy)-4-(4-fluorophenyl)butan-1-ol (869588-30-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂CO₃; H₂ / Pd/C / ethanol / 19 h

2: 3.643 g / H₂ / Pd/C / ethanol / 2.25 h

With hydrogen; sodium carbonate; palladium on activated charcoal; In ethanol;

DOI:10.1039/b510100j

upstream raw materials:

4-benzyloxy-1-(4-fluorophenyl)but-2-yn-1-ol

4-fluorobenzaldehyde

Downstream raw materials:

4-(tert-butyl-dimethyl-silanyloxy)-4-(4-fluoro-phenyl)-butyraldehyde

[4-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-2-(4-fluoro-phenyl)-3,4-dihydro-2H-pyrazol-3-yl]-methanol

2-{2-(4-fluorophenyl)-4-[3-(4-fluorophenyl)-3-hydroxypropyl]-3,4-dihydro-2H-pyrazol-3-yl}-4H-oxazol-5-one

4-[4-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-2-(4-fluoro-phenyl)-3,4-dihydro-2H-pyrazol-3-ylmethoxy]-phenol