1-chloro-3-(4-fluorophenyl)-6-fluoroindan

Base Information

Chemical Name:1-chloro-3-(4-fluorophenyl)-6-fluoroindan
CAS No.:344755-05-1
Molecular Formula:C₁₅H₁₁ClF₂
Molecular Weight:264.702
Hs Code.:

Synonyms:1-chloro-3-(4-fluorophenyl)-6-fluoroindan

Suppliers and Price of 1-chloro-3-(4-fluorophenyl)-6-fluoroindan

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-chloro-3-(4-fluorophenyl)-6-fluoroindan

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-chloro-3-(4-fluorophenyl)-6-fluoroindan

There total 7 articles about 1-chloro-3-(4-fluorophenyl)-6-fluoroindan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-fluoro-3-(4-fluorophenyl)-indan-1-ol

: 344755-05-1
1-chloro-3-(4-fluorophenyl)-6-fluoroindan

Guidance literature:: With thionyl chloride; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; toluene;

Reference yield:

: 80272-65-7
cis-6-fluoro-3-(4-fluorophenyl)indan-1-ol

: 344755-05-1
1-chloro-3-(4-fluorophenyl)-6-fluoroindan

Guidance literature:: With thionyl chloride; In toluene; 1.) RT, 30 min, 2.) from 50 deg C to 55 deg C, 1 h;
DOI:10.1021/jm00361a002

Reference yield:

: 342-75-6
3,3-bis(4-fluorophenyl)-propanoic acid

: 344755-05-1
1-chloro-3-(4-fluorophenyl)-6-fluoroindan

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / polyphosphoric acid (PPA) / 2 h / 105 °C

2: 1.) potassium tri-sec-butyl borohydride (K-Selectride), 2.) 3 N aq. NaOH, 35percent H₂O₂ / 1.) THF, 0 deg C, 40 min

3: SOCl₂ / toluene / 1.) RT, 30 min, 2.) from 50 deg C to 55 deg C, 1 h

With sodium hydroxide; thionyl chloride; PPA; Polyphosphoric acid (PPA); dihydrogen peroxide; potassium tri-sec-butyl-borohydride; In toluene;
DOI:10.1021/jm00361a002