4-(4-(difluoromethoxy)phenyl)-4-(3-(2-fluoropyridin-3-yl)phenyl)-4,5-dihydrooxazol-2-amine

Base Information

Chemical Name:4-(4-(difluoromethoxy)phenyl)-4-(3-(2-fluoropyridin-3-yl)phenyl)-4,5-dihydrooxazol-2-amine
CAS No.:1398519-62-4
Molecular Formula:C₂₁H₁₆F₃N₃O₂
Molecular Weight:399.372
Hs Code.:

Synonyms:4-(4-(difluoromethoxy)phenyl)-4-(3-(2-fluoropyridin-3-yl)phenyl)-4,5-dihydrooxazol-2-amine

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Chemical Property of 4-(4-(difluoromethoxy)phenyl)-4-(3-(2-fluoropyridin-3-yl)phenyl)-4,5-dihydrooxazol-2-amine

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Technology Process of 4-(4-(difluoromethoxy)phenyl)-4-(3-(2-fluoropyridin-3-yl)phenyl)-4,5-dihydrooxazol-2-amine

There total 3 articles about 4-(4-(difluoromethoxy)phenyl)-4-(3-(2-fluoropyridin-3-yl)phenyl)-4,5-dihydrooxazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1415795-91-3
C₁₆H₁₃BrF₂N₂O₂

: 174669-73-9
(2-fluoro-pyridin-3-yl)boronic acid

: 1398519-62-4
4-(4-(difluoromethoxy)phenyl)-4-(3-(2-fluoropyridin-3-yl)phenyl)-4,5-dihydrooxazol-2-amine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; at 125 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm300598e

Reference yield:

: 1180015-70-6
1-bromo-3-(1-(4-(difluoromethoxy)phenyl)vinyl)benzene

: 1398519-62-4
4-(4-(difluoromethoxy)phenyl)-4-(3-(2-fluoropyridin-3-yl)phenyl)-4,5-dihydrooxazol-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethyl ether / -6 - 20 °C

1.2: 4 h

2.1: ammonium hydroxide / water; acetone / 20 °C

2.2: Chiralcel OJ / Resolution of racemate; Supercritical conditions

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane / 16 h / 125 °C / Inert atmosphere

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; diethyl ether; water; acetone; 3.1: |Suzuki Coupling;
DOI:10.1021/jm300598e

Reference yield:

: 1398519-75-9
1-bromo-3-(1-(4-(difluoromethoxy)phenyl)-2-iodo-1-cyanatoethyl)benzene

: 1398519-62-4
4-(4-(difluoromethoxy)phenyl)-4-(3-(2-fluoropyridin-3-yl)phenyl)-4,5-dihydrooxazol-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium hydroxide / water; acetone / 20 °C

1.2: Chiralcel OJ / Resolution of racemate; Supercritical conditions

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane / 16 h / 125 °C / Inert atmosphere

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; acetone; 2.1: |Suzuki Coupling;
DOI:10.1021/jm300598e