Cerivastatin, sodium salt

Base Information

• Chemical Name: Cerivastatin, sodium salt
• CAS No.: 143201-11-0
• Molecular Formula: C26H33FNNaO5
• Molecular Weight: 481.54
• Mol file: 143201-11-0.mol

Synonyms:Cerivastatin, sodium salt;143201-11-0;SCHEMBL44240;SCHEMBL388705;AKOS040732790

Chemical Property of Cerivastatin, sodium salt

Chemical Property:

• Appearance/Colour: Solid
• Vapor Pressure: 1.37E-17mmHg at 25°C
• Melting Point: 197-199 °C
• Boiling Point: 646.3 °C at 760 mmHg
• Flash Point: 344.7 °C
• PSA: 99.88000
• LogP: 4.88070
• Storage Temp.: Hygroscopic, Store under Inert atmosphere -20°C Freezer
• Solubility.: H2O: ≥5mg/mL
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 11
• Exact Mass: 482.23187063
• Heavy Atom Count: 34
• Complexity: 620

Purity/Quality:

99% ^*data from raw suppliers

CerivastatinSodiumSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C1=C(C(=C(C(=N1)C(C)C)COC)C2=CC=C(C=C2)F)C=CC(CC(CC(=O)O)O)O.[Na]
• Isomeric SMILES: CC(C)C1=C(C(=C(C(=N1)C(C)C)COC)C2=CC=C(C=C2)F)/C=C/[C@H](C[C@H](CC(=O)O)O)O.[Na]
• Description: Lipobay was launched in Denmark, Germany and the UK for treatment of primary hypercholesteremia types Ⅱa and Ⅱb. It is available through a nine step synthesis beginning with the Hantsch reaction of ethyl 3-amino-4-methylpent-2-enoate and 4-(ethoxycarbonyl)-5-(4-fluorophenyl)-2-methylpent-4-en-3-one. Lipobay acts as an HMG-CoA reductase inhibitor showing a high liver selectivity (50 fold). In vitro Lipobay had a higher affinity (110x) for the enzyme than does Lovastatin, Simvastatin and pravastatin which resulted in a lower ED50, in vivo compared to Lovastatin. Three metabolites generated by the CYP3A4 enzyme system were equal to the parent in activity. Lipobay was as effective as Gemfibrozil in type lib hypercholesteremia and had no age or gender effects. It decreased plasma levels of VLDL and LDL cholesterol by a mechanism similar to other HMG-CoA reductase inhibitors. The (-)- antipode is completely inactive indicating a high stereospecificity by the enzyme. It is therapeutically useful at ultra-low doses which may minimize any drug-drug interactions.
• Uses: Cerivastatin is a competitive inhibitor of HMG-CoA reductase. Cerivastatin sodium salt hydrate has been used as a supplement in cell culture. A competitive inhibitor of HMG-CoA reductase.