(1S,3R,4R,5S)-4-acetyl-5-[3-(2-nitrophenyloxy)-propyl]-1-benzoylcyclohexane-1,3-carbolactone

Base Information

Chemical Name:(1S,3R,4R,5S)-4-acetyl-5-[3-(2-nitrophenyloxy)-propyl]-1-benzoylcyclohexane-1,3-carbolactone
CAS No.:866217-87-0
Molecular Formula:C₂₅H₂₅NO₉
Molecular Weight:483.475
Hs Code.:

Synonyms:(1S,3R,4R,5S)-4-acetyl-5-[3-(2-nitrophenyloxy)-propyl]-1-benzoylcyclohexane-1,3-carbolactone

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Chemical Property of (1S,3R,4R,5S)-4-acetyl-5-[3-(2-nitrophenyloxy)-propyl]-1-benzoylcyclohexane-1,3-carbolactone

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Technology Process of (1S,3R,4R,5S)-4-acetyl-5-[3-(2-nitrophenyloxy)-propyl]-1-benzoylcyclohexane-1,3-carbolactone

There total 3 articles about (1S,3R,4R,5S)-4-acetyl-5-[3-(2-nitrophenyloxy)-propyl]-1-benzoylcyclohexane-1,3-carbolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 866217-85-8
(1S,3R,4R,5S)-4-acetyl-5-(3-bromopropyl)-1-benzoylcyclohexane-1,3-carbolactone

: 88-75-5,78813-12-4
2-hydroxynitrobenzene

: 866217-87-0
(1S,3R,4R,5S)-4-acetyl-5-[3-(2-nitrophenyloxy)-propyl]-1-benzoylcyclohexane-1,3-carbolactone

Guidance literature:: With sodium hydride; potassium iodide; In acetonitrile; for 18h; Heating;
DOI:10.1039/b507156a

Reference yield:

: 866217-84-7
(1S,3R,4R,5S)-1-acetyl-5-allyl-4-benzoylcyclohexane-1,3-carbolactone

: 866217-87-0
(1S,3R,4R,5S)-4-acetyl-5-[3-(2-nitrophenyloxy)-propyl]-1-benzoylcyclohexane-1,3-carbolactone

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / HBr; AIBN / CCl₄ / 0.75 h / 20 °C / anti-Markovnikov bromination

2: 11 percent / NaH; KI / acetonitrile / 18 h / Heating

With 2,2'-azobis(isobutyronitrile); hydrogen bromide; sodium hydride; potassium iodide; In tetrachloromethane; acetonitrile;
DOI:10.1039/b507156a

Reference yield:

: 183474-89-7
(1S,3S,4R,5R)-3-allyl-1-hydroxy-7-oxo-6-oxabicyclo[3.2.1]oct-4-yl benzoate

: 866217-87-0
(1S,3R,4R,5S)-4-acetyl-5-[3-(2-nitrophenyloxy)-propyl]-1-benzoylcyclohexane-1,3-carbolactone

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / pyridine / 12 h / 20 °C

2: 97 percent / HBr; AIBN / CCl₄ / 0.75 h / 20 °C / anti-Markovnikov bromination

3: 11 percent / NaH; KI / acetonitrile / 18 h / Heating

With pyridine; 2,2'-azobis(isobutyronitrile); hydrogen bromide; sodium hydride; potassium iodide; In tetrachloromethane; acetonitrile;
DOI:10.1039/b507156a