(1S,3R,4R,6S,7S)-1-(tert-butyldiphenylsilyloxymethyl)-6-methyl-7-(2-naphthylmethyloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Base Information

Chemical Name:(1S,3R,4R,6S,7S)-1-(tert-butyldiphenylsilyloxymethyl)-6-methyl-7-(2-naphthylmethyloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane
CAS No.:1197032-94-2
Molecular Formula:C₃₉H₄₂N₂O₆Si
Molecular Weight:662.858
Hs Code.:

Synonyms:(1S,3R,4R,6S,7S)-1-(tert-butyldiphenylsilyloxymethyl)-6-methyl-7-(2-naphthylmethyloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Suppliers and Price of (1S,3R,4R,6S,7S)-1-(tert-butyldiphenylsilyloxymethyl)-6-methyl-7-(2-naphthylmethyloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,3R,4R,6S,7S)-1-(tert-butyldiphenylsilyloxymethyl)-6-methyl-7-(2-naphthylmethyloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,3R,4R,6S,7S)-1-(tert-butyldiphenylsilyloxymethyl)-6-methyl-7-(2-naphthylmethyloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

There total 12 articles about (1S,3R,4R,6S,7S)-1-(tert-butyldiphenylsilyloxymethyl)-6-methyl-7-(2-naphthylmethyloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1197032-93-1
C₄₂H₄₈N₂O₁₀SSi

: 1197032-94-2
(1S,3R,4R,6S,7S)-1-(tert-butyldiphenylsilyloxymethyl)-6-methyl-7-(2-naphthylmethyloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 16h;
DOI:10.1021/jo902560f

Reference yield:

: 1057385-93-9
(3aR,5S,6R,6aR)-2,2-dimethyl-6-(naphthalen-2-ylmethoxy)tetrahydrofuro[3,2-d][1,3]dioxole-5-carbaldehyde

: 1197032-94-2
(1S,3R,4R,6S,7S)-1-(tert-butyldiphenylsilyloxymethyl)-6-methyl-7-(2-naphthylmethyloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide / water; tetrahydrofuran / 72 h / 20 °C / Cooling with ice

2.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2.2: 2 h / 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C

3.2: 1 h / -78 °C / Cooling with ice

4.1: cerium(III) chloride / tetrahydrofuran / 1.58 h / 0 - 20 °C / Cooling with ice

4.2: 3 h / -78 °C

4.3: -78 - 20 °C

5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C

5.2: 1 h / -78 °C / Cooling with ice

6.1: lithium borohydride; methanol / tetrahydrofuran / 2 h / -78 °C

7.1: dmap; triethylamine / dichloromethane / 2.5 h / 0 °C

8.1: sulfuric acid; acetic acid / 3 h / 20 °C

9.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 0.25 h / 40 °C

9.2: 2 h / Cooling with ice; Reflux

9.3: 16 h / 20 °C

With methanol; dmap; lithium borohydride; N,O-bis-(trimethylsilyl)-acetamide; cerium(III) chloride; oxalyl dichloride; sulfuric acid; acetic acid; dimethyl sulfoxide; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile; 3.1: Swern Oxidation / 5.1: Swern Oxidation;

Reference yield:

: 939-26-4
2-bromomethylnaphthyl bromide

: 1197032-94-2
(1S,3R,4R,6S,7S)-1-(tert-butyldiphenylsilyloxymethyl)-6-methyl-7-(2-naphthylmethyloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 12 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / Cooling with ice

2.1: acetic acid / water / 16 h / 20 °C

3.1: sodium periodate / 1,4-dioxane; water / 1 h

4.1: sodium hydroxide / water; tetrahydrofuran / 72 h / 20 °C / Cooling with ice

5.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

5.2: 2 h / 20 °C

6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C

6.2: 1 h / -78 °C / Cooling with ice

7.1: cerium(III) chloride / tetrahydrofuran / 1.58 h / 0 - 20 °C / Cooling with ice

7.2: 3 h / -78 °C

7.3: -78 - 20 °C

8.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C

8.2: 1 h / -78 °C / Cooling with ice

9.1: lithium borohydride; methanol / tetrahydrofuran / 2 h / -78 °C

10.1: dmap; triethylamine / dichloromethane / 2.5 h / 0 °C

11.1: sulfuric acid; acetic acid / 3 h / 20 °C

12.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 0.25 h / 40 °C

12.2: 2 h / Cooling with ice; Reflux

12.3: 16 h / 20 °C

With methanol; dmap; sodium periodate; lithium borohydride; N,O-bis-(trimethylsilyl)-acetamide; cerium(III) chloride; oxalyl dichloride; sulfuric acid; sodium hydride; acetic acid; dimethyl sulfoxide; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil; 6.1: Swern Oxidation / 8.1: Swern Oxidation;