3-{3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-[4-(trifluoromethyl) phenyl]-1H-pyrazol-1-yl}-6-methoxypyridazine

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Chemical Name:3-{3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-[4-(trifluoromethyl) phenyl]-1H-pyrazol-1-yl}-6-methoxypyridazine
CAS No.:1339036-00-8
Molecular Formula:C₃₃H₃₇F₃N₆O₂
Molecular Weight:606.691
Hs Code.:

Synonyms:3-{3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-[4-(trifluoromethyl) phenyl]-1H-pyrazol-1-yl}-6-methoxypyridazine

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Chemical Property of 3-{3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-[4-(trifluoromethyl) phenyl]-1H-pyrazol-1-yl}-6-methoxypyridazine

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Technology Process of 3-{3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-[4-(trifluoromethyl) phenyl]-1H-pyrazol-1-yl}-6-methoxypyridazine

There total 4 articles about 3-{3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-[4-(trifluoromethyl) phenyl]-1H-pyrazol-1-yl}-6-methoxypyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 956-61-6
1-(4-tert-butylbenzyl)piperazine

: 1254703-74-6
C₁₈H₁₅F₃N₄O₃

: 1339036-00-8
3-{3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-[4-(trifluoromethyl) phenyl]-1H-pyrazol-1-yl}-6-methoxypyridazine

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2011.08.009

Reference yield:

: 1254703-67-7
C₁₇H₁₂ClF₃N₄O₂

: 1339036-00-8
3-{3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-[4-(trifluoromethyl) phenyl]-1H-pyrazol-1-yl}-6-methoxypyridazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / Reflux

1.2: Acidic conditions

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.08.009

Reference yield:

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 1339036-00-8
3-{3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-[4-(trifluoromethyl) phenyl]-1H-pyrazol-1-yl}-6-methoxypyridazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: Alkaline conditions

2.1: triethylamine / methanol / Reflux

3.1: methanol / Reflux

3.2: Acidic conditions

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.08.009