(S)-3-(2,6-Difluoro-phenyl)-2-methyl-2-{[1-naphthalen-2-yl-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester

Base Information

• Chemical Name: (S)-3-(2,6-Difluoro-phenyl)-2-methyl-2-{[1-naphthalen-2-yl-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester
• CAS No.: 1027938-56-2
• Molecular Formula: C₂₅H₂₅F₂NO₂
• Molecular Weight: 409.476

Synonyms:(S)-3-(2,6-Difluoro-phenyl)-2-methyl-2-{[1-naphthalen-2-yl-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester

Chemical Property of (S)-3-(2,6-Difluoro-phenyl)-2-methyl-2-{[1-naphthalen-2-yl-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester

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Technology Process of (S)-3-(2,6-Difluoro-phenyl)-2-methyl-2-{[1-naphthalen-2-yl-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester

There total 3 articles about (S)-3-(2,6-Difluoro-phenyl)-2-methyl-2-{[1-naphthalen-2-yl-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-Difluorobenzyl bromide (85118-00-9) + tert-butyl (2S)-2-[(E)-[(naphthalen-2-yl)methylidene]amino]propanoate → (S)-3-(2,6-Difluoro-phenyl)-2-methyl-2-{[1-naphthalen-2-yl-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester (1027938-56-2)

Guidance literature:

With rubidium hydroxide; O⁽⁹⁾-All-N-(2',3',4'-trifluorobenzyl)hydrocinchonidinium bromide; In toluene; at -35 ℃; for 10h;

DOI:10.1021/jo034006t

Reference yield:

Ala-OtBu (21691-50-9) → (S)-3-(2,6-Difluoro-phenyl)-2-methyl-2-{[1-naphthalen-2-yl-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester (1027938-56-2)

Guidance literature:

Multi-step reaction with 2 steps

1: RbOH; O⁽⁹⁾-All-N-2',3',4'-trifluorobenzylhydrocinchonidium Br^(1-) / toluene / 10 h / -35 °C

With rubidium hydroxide; O⁽⁹⁾-All-N-(2',3',4'-trifluorobenzyl)hydrocinchonidinium bromide; In toluene;

DOI:10.1021/jo034006t

Reference yield:

β-naphthaldehyde (66-99-9) → (S)-3-(2,6-Difluoro-phenyl)-2-methyl-2-{[1-naphthalen-2-yl-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester (1027938-56-2)

Guidance literature:

Multi-step reaction with 2 steps

1: RbOH; O⁽⁹⁾-All-N-2',3',4'-trifluorobenzylhydrocinchonidium Br^(1-) / toluene / 10 h / -35 °C

With rubidium hydroxide; O⁽⁹⁾-All-N-(2',3',4'-trifluorobenzyl)hydrocinchonidinium bromide; In toluene;

DOI:10.1021/jo034006t

upstream raw materials:

2,6-Difluorobenzyl bromide

Ala-OtBu

β-naphthaldehyde

Downstream raw materials:

2-amino-3-(2,6-difluoro-phenyl)-2-methyl-propionic acid tert-butyl ester

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