5-hydroxy-7-methoxy-2-(4-(2-pyrrolidin-1-yl-ethoxy)phenyl)chromen-4-one

Base Information

Chemical Name:5-hydroxy-7-methoxy-2-(4-(2-pyrrolidin-1-yl-ethoxy)phenyl)chromen-4-one
CAS No.:1612891-92-5
Molecular Formula:C₂₂H₂₃NO₅
Molecular Weight:381.428
Hs Code.:

Synonyms:5-hydroxy-7-methoxy-2-(4-(2-pyrrolidin-1-yl-ethoxy)phenyl)chromen-4-one

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Chemical Property of 5-hydroxy-7-methoxy-2-(4-(2-pyrrolidin-1-yl-ethoxy)phenyl)chromen-4-one

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Technology Process of 5-hydroxy-7-methoxy-2-(4-(2-pyrrolidin-1-yl-ethoxy)phenyl)chromen-4-one

There total 5 articles about 5-hydroxy-7-methoxy-2-(4-(2-pyrrolidin-1-yl-ethoxy)phenyl)chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1612891-78-7
5,7-dimethoxy-2-(4-(2-pyrrolidin-1-ylethoxy)phenyl)chromen-4-one

: 1612891-92-5
5-hydroxy-7-methoxy-2-(4-(2-pyrrolidin-1-yl-ethoxy)phenyl)chromen-4-one

Guidance literature:: With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.04.043

Reference yield:

: 90-24-4
2-hydroxy-4,6-dimethoxyacetophenone

: 1612891-92-5
5-hydroxy-7-methoxy-2-(4-(2-pyrrolidin-1-yl-ethoxy)phenyl)chromen-4-one

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / ethanol; water / 16 h / 20 °C / Inert atmosphere

2: iodine / dimethyl sulfoxide / 4 h / 140 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / methanol / 4 h / 90 °C / Inert atmosphere

4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

5: potassium iodide; potassium carbonate / acetone / 18 h / 0 - 75 °C / Inert atmosphere

6: boron tribromide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; iodine; boron tribromide; potassium carbonate; triphenylphosphine; potassium iodide; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; acetone; 1: |Aldol Condensation / 4: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2014.04.043

Reference yield:

: 76554-28-4
C₂₀H₂₀O₅

: 1612891-92-5
5-hydroxy-7-methoxy-2-(4-(2-pyrrolidin-1-yl-ethoxy)phenyl)chromen-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: iodine / dimethyl sulfoxide / 4 h / 140 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / methanol / 4 h / 90 °C / Inert atmosphere

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

4: potassium iodide; potassium carbonate / acetone / 18 h / 0 - 75 °C / Inert atmosphere

5: boron tribromide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; iodine; boron tribromide; potassium carbonate; triphenylphosphine; potassium iodide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; acetone; 3: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2014.04.043