(S)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yl 2-hydroxy-4-methoxy-5-chloro-6-vinylbenzoate

Base Information

Chemical Name:(S)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yl 2-hydroxy-4-methoxy-5-chloro-6-vinylbenzoate
CAS No.:1427278-53-2
Molecular Formula:C₂₆H₃₇ClO₈
Molecular Weight:513.028
Hs Code.:

Synonyms:(S)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yl 2-hydroxy-4-methoxy-5-chloro-6-vinylbenzoate

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Chemical Property of (S)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yl 2-hydroxy-4-methoxy-5-chloro-6-vinylbenzoate

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Technology Process of (S)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yl 2-hydroxy-4-methoxy-5-chloro-6-vinylbenzoate

There total 2 articles about (S)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yl 2-hydroxy-4-methoxy-5-chloro-6-vinylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1388144-77-1
(R)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-ol

: 1427278-57-6
3-chloro-6-hydroxy-4-methoxy-2-vinylbenzoic acid

: 1427278-53-2
(S)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yl 2-hydroxy-4-methoxy-5-chloro-6-vinylbenzoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; for 1.5h; Inert atmosphere;
DOI:10.1016/j.tet.2013.02.033

Reference yield:

: 3-chloro-6-hydroxy-4-methoxy-2-vinylbenzoic acid

: 1427278-53-2
(S)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yl 2-hydroxy-4-methoxy-5-chloro-6-vinylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium chlorite; aminosulfonic acid / tetrahydrofuran; water / 2 h / 0 - 20 °C

2: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 1.5 h / Inert atmosphere

With sodium chlorite; di-isopropyl azodicarboxylate; aminosulfonic acid; triphenylphosphine; In tetrahydrofuran; water; toluene; 2: |Mitsunobu Displacement;
DOI:10.1016/j.tet.2013.02.033

Reference yield: 40.0%

: 1427278-53-2
(S)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yl 2-hydroxy-4-methoxy-5-chloro-6-vinylbenzoate

: C₅₀H₇₀Cl₂O₁₆

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 40 ℃; for 8h; Reagent/catalyst; Inert atmosphere;
DOI:10.1016/j.tet.2013.02.033