(RS)-N-benzyl-2-(2,5-dioxo-1-pyrrolidinyl)-2-fluoroethanamide

Base Information

• Chemical Name: (RS)-N-benzyl-2-(2,5-dioxo-1-pyrrolidinyl)-2-fluoroethanamide
• CAS No.: 216578-88-0
• Molecular Formula: C₁₃H₁₃FN₂O₃
• Molecular Weight: 264.256
• Mol file: 216578-88-0.mol

Synonyms:(RS)-N-benzyl-2-(2,5-dioxo-1-pyrrolidinyl)-2-fluoroethanamide

Chemical Property of (RS)-N-benzyl-2-(2,5-dioxo-1-pyrrolidinyl)-2-fluoroethanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (RS)-N-benzyl-2-(2,5-dioxo-1-pyrrolidinyl)-2-fluoroethanamide

There total 4 articles about (RS)-N-benzyl-2-(2,5-dioxo-1-pyrrolidinyl)-2-fluoroethanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

Succinimide (123-56-8,89963-74-6) + (RS)-N-benzyl-2-fluoro-2-iodoethanamide (216578-85-7) → (RS)-N-benzyl-2-(2,5-dioxo-1-pyrrolidinyl)-2-fluoroethanamide (216578-88-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1016/S0040-4039(98)01658-X

Reference yield:

benzylamine (100-46-9) → (RS)-N-benzyl-2-(2,5-dioxo-1-pyrrolidinyl)-2-fluoroethanamide (216578-88-0)

Guidance literature:

Multi-step reaction with 4 steps

1: diethyl ether / Ambient temperature

2: aq. H₂SO₄

3: 79 percent / NaI / acetone / Heating

4: 83 percent / NaH / dimethylformamide / Ambient temperature

With sulfuric acid; sodium hydride; sodium iodide; In diethyl ether; N,N-dimethyl-formamide; acetone;

DOI:10.1016/S0040-4039(98)01658-X

Reference yield:

Benzyl-((Z)-2-chloro-1,2-difluoro-vinyl)-amine → (RS)-N-benzyl-2-(2,5-dioxo-1-pyrrolidinyl)-2-fluoroethanamide (216578-88-0)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. H₂SO₄

2: 79 percent / NaI / acetone / Heating

3: 83 percent / NaH / dimethylformamide / Ambient temperature

With sulfuric acid; sodium hydride; sodium iodide; In N,N-dimethyl-formamide; acetone;

DOI:10.1016/S0040-4039(98)01658-X

upstream raw materials:

Succinimide

(RS)-N-benzyl-2-fluoro-2-iodoethanamide

benzylamine

(RS)-N-benzyl-2-chloro-2-fluoroethanamide

Downstream raw materials:

C₂₇H₃₀N₄O₃

N-Benzyl-2-fluoro-2-(2-hydroxy-5-oxo-pyrrolidin-1-yl)-acetamide