2-[(2E)-2-{[3-(biphenyl-4-yl)-1H-pyrazol-4-yl]methylidene}hydrazinyl]-5,7-dichloro-1,3-benzoxazole

Base Information

• Chemical Name: 2-[(2E)-2-{[3-(biphenyl-4-yl)-1H-pyrazol-4-yl]methylidene}hydrazinyl]-5,7-dichloro-1,3-benzoxazole
• CAS No.: 1430812-59-1
• Molecular Formula: C₂₃H₁₅Cl₂N₅O
• Molecular Weight: 448.311
• Mol file: 1430812-59-1.mol

Synonyms:2-[(2E)-2-{[3-(biphenyl-4-yl)-1H-pyrazol-4-yl]methylidene}hydrazinyl]-5,7-dichloro-1,3-benzoxazole

Chemical Property of 2-[(2E)-2-{[3-(biphenyl-4-yl)-1H-pyrazol-4-yl]methylidene}hydrazinyl]-5,7-dichloro-1,3-benzoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2E)-2-{[3-(biphenyl-4-yl)-1H-pyrazol-4-yl]methylidene}hydrazinyl]-5,7-dichloro-1,3-benzoxazole

There total 4 articles about 2-[(2E)-2-{[3-(biphenyl-4-yl)-1H-pyrazol-4-yl]methylidene}hydrazinyl]-5,7-dichloro-1,3-benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

C16H12N2O (1018677-48-9) + 5,7-dichloro-2-hydrazinyl-1,3-benzoxazole (1267064-00-5) → 2-[(2E)-2-{[3-(biphenyl-4-yl)-1H-pyrazol-4-yl]methylidene}hydrazinyl]-5,7-dichloro-1,3-benzoxazole (1430812-59-1)

Guidance literature:

DOI:10.1016/j.ejmech.2012.12.057

Reference yield:

biphenyl-4-acetaldehyde (92-91-1) → 2-[(2E)-2-{[3-(biphenyl-4-yl)-1H-pyrazol-4-yl]methylidene}hydrazinyl]-5,7-dichloro-1,3-benzoxazole (1430812-59-1)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; sodium acetate / ethanol

2: trichlorophosphate / N,N-dimethyl-formamide

With hydrogenchloride; sodium acetate; trichlorophosphate; In ethanol; N,N-dimethyl-formamide; 2: |Vilsmeier Reaction;

DOI:10.1016/j.ejmech.2012.12.057

Reference yield:

4-phenylacetophenone semicarbazone (120446-10-8,52376-83-7) → 2-[(2E)-2-{[3-(biphenyl-4-yl)-1H-pyrazol-4-yl]methylidene}hydrazinyl]-5,7-dichloro-1,3-benzoxazole (1430812-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / N,N-dimethyl-formamide

With trichlorophosphate; In N,N-dimethyl-formamide; 1: |Vilsmeier Reaction;

DOI:10.1016/j.ejmech.2012.12.057

upstream raw materials:

C₁₆H₁₂N₂O

5,7-dichloro-2-hydrazinyl-1,3-benzoxazole

biphenyl-4-acetaldehyde

4-phenylacetophenone semicarbazone