(4S)-3-{(2R,3R)-2-[(2R)-2-(4-fluorophenyl)-2-(1,1,2,2-tetramethyl-1-silapropoxy)ethylthio]-3-[(4-iodophenyl)amino]-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)phenyl]propanoyl}-4-phenyl-1,3-oxazolidin-2-one

Base Information

Chemical Name:(4S)-3-{(2R,3R)-2-[(2R)-2-(4-fluorophenyl)-2-(1,1,2,2-tetramethyl-1-silapropoxy)ethylthio]-3-[(4-iodophenyl)amino]-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)phenyl]propanoyl}-4-phenyl-1,3-oxazolidin-2-one
CAS No.:1056209-26-7
Molecular Formula:C₄₄H₅₆FIN₂O₅SSi₂
Molecular Weight:927.079
Hs Code.:

(4S)-3-{(2R,3R)-2-[(2R)-2-(4-fluorophenyl)-2-(1,1,2,2-tetramethyl-1-silapropoxy)ethylthio]-3-[(4-iodophenyl)amino]-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)phenyl]propanoyl}-4-phenyl-1,3-oxazolidin-2-one

Synonyms:(4S)-3-{(2R,3R)-2-[(2R)-2-(4-fluorophenyl)-2-(1,1,2,2-tetramethyl-1-silapropoxy)ethylthio]-3-[(4-iodophenyl)amino]-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)phenyl]propanoyl}-4-phenyl-1,3-oxazolidin-2-one

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Chemical Property of (4S)-3-{(2R,3R)-2-[(2R)-2-(4-fluorophenyl)-2-(1,1,2,2-tetramethyl-1-silapropoxy)ethylthio]-3-[(4-iodophenyl)amino]-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)phenyl]propanoyl}-4-phenyl-1,3-oxazolidin-2-one

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Technology Process of (4S)-3-{(2R,3R)-2-[(2R)-2-(4-fluorophenyl)-2-(1,1,2,2-tetramethyl-1-silapropoxy)ethylthio]-3-[(4-iodophenyl)amino]-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)phenyl]propanoyl}-4-phenyl-1,3-oxazolidin-2-one

There total 1 articles about (4S)-3-{(2R,3R)-2-[(2R)-2-(4-fluorophenyl)-2-(1,1,2,2-tetramethyl-1-silapropoxy)ethylthio]-3-[(4-iodophenyl)amino]-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)phenyl]propanoyl}-4-phenyl-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1056209-21-2
(4S)-3-{2-[(2R)-2-(4-fluorophenyl)-2-(1,1,2,2-tetramethyl-1-silapropoxy)ethylthio]acetyl}-4-phenyl-1,3-oxazolidin-2-one

: 1056209-23-4
1-(4-[2-(4-iodophenyl)-2-azavinyl]phenoxy)-1,1,2,2-tetramethyl-1-silapropane

: 1056209-26-7
(4S)-3-{(2R,3R)-2-[(2R)-2-(4-fluorophenyl)-2-(1,1,2,2-tetramethyl-1-silapropoxy)ethylthio]-3-[(4-iodophenyl)amino]-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)phenyl]propanoyl}-4-phenyl-1,3-oxazolidin-2-one

Guidance literature:: (4S)-3-{2-[(2R)-2-(4-fluorophenyl)-2-(1,1,2,2-tetramethyl-1-silapropoxy)ethylthio]acetyl}-4-phenyl-1,3-oxazolidin-2-one; 1-(4-[2-(4-iodophenyl)-2-azavinyl]phenoxy)-1,1,2,2-tetramethyl-1-silapropane; With chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -5 ℃; for 1h; Inert atmosphere;

With titanium tetrachloride; In dichloromethane; at -35 - -25 ℃; for 4.5h;

Reference yield: 44.0%

: 1056209-26-7
(4S)-3-{(2R,3R)-2-[(2R)-2-(4-fluorophenyl)-2-(1,1,2,2-tetramethyl-1-silapropoxy)ethylthio]-3-[(4-iodophenyl)amino]-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)phenyl]propanoyl}-4-phenyl-1,3-oxazolidin-2-one

: 1056209-28-9
(3R,4R)-3-[(2R)-2-(4-fluorophenyl)-2-(1,1,2,2-tetramethyl-1-silapropoxy)ethylthio]-1-(4-iodophenyl)-4-[4-(1,1,2,2-tetramethyl-1-silapropoxy)phenyl]azetidin-2-one

Guidance literature:: (4S)-3-{(2R,3R)-2-[(2R)-2-(4-fluorophenyl)-2-(1,1,2,2-tetramethyl-1-silapropoxy)ethylthio]-3-[(4-iodophenyl)amino]-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)phenyl]propanoyl}-4-phenyl-1,3-oxazolidin-2-one; With N,O-bis-(trimethylsilyl)-acetamide; In tert-butyl methyl ether; at 20 ℃;

tetrabutyl ammonium fluoride; In tetrahydrofuran; tert-butyl methyl ether; at 20 ℃; for 5h;