4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]benzenecarboxaldehyde

Base Information

• Chemical Name: 4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]benzenecarboxaldehyde
• CAS No.: 1410789-63-7
• Molecular Formula: C₂₄H₂₆O
• Molecular Weight: 330.47
• Mol file: 1410789-63-7.mol

Synonyms:4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]benzenecarboxaldehyde

Chemical Property of 4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]benzenecarboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]benzenecarboxaldehyde

There total 2 articles about 4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]benzenecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.5%

4-bromo-α-phenyl-α-(1-tricyclo[3.3.1.13,7]decyl)methylbenzene (1410789-54-6) → 4-[α-(1-tricyclo[3.3.1.13,7]decyl)phenylmethyl]benzenecarboxaldehyde (1410789-63-7)

Guidance literature:

4-bromo-α-phenyl-α-(1-tricyclo[3.3.1.1^3,7]decyl)methylbenzene; With n-butyllithium; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; at -80 - 20 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;

DOI:10.1021/jm3013008

Reference yield:

α-(4-bromophenyl)-α-phenyl-1-tricyclo[3.3.1.13,7]-decanemethanol (1410789-53-5) → 4-[α-(1-tricyclo[3.3.1.13,7]decyl)phenylmethyl]benzenecarboxaldehyde (1410789-63-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

1.3: 0 °C

2.1: n-butyllithium / tetrahydrofuran; hexane; N,N-dimethyl-formamide / 2 h / -80 - 20 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

With n-butyllithium; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm3013008

Reference yield: 90.0%

4-[α-(1-tricyclo[3.3.1.13,7]decyl)phenylmethyl]benzenecarboxaldehyde (1410789-63-7) → 4-[α-(1-tricyclo[3.3.1.13,7]decyl)phenylmethyl]benzenemethanol (1410789-64-8)

Guidance literature:

4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]benzenecarboxaldehyde; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Reflux;

With sodium hydroxide; In tetrahydrofuran; ethanol; water; at 0 ℃;

DOI:10.1021/jm3013008

upstream raw materials:

4-bromo-α-phenyl-α-(1-tricyclo[3.3.1.1^3,7]decyl)methylbenzene

α-(4-bromophenyl)-α-phenyl-1-tricyclo[3.3.1.1^3,7]-decanemethanol

Downstream raw materials:

C₃₀H₃₉N

4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]benzenemethanol

4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]phenylmethyl chloride

4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]benzeneacetonitrile