N-α-boc-L-tryptophan 3,5-dimethylbenzyl ester

Base Information

• Chemical Name: N-α-boc-L-tryptophan 3,5-dimethylbenzyl ester
• CAS No.: 148451-85-8
• Molecular Formula: C₂₅H₃₀N₂O₄
• Molecular Weight: 422.524
• Mol file: 148451-85-8.mol

Synonyms:N-α-boc-L-tryptophan 3,5-dimethylbenzyl ester

Chemical Property of N-α-boc-L-tryptophan 3,5-dimethylbenzyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-α-boc-L-tryptophan 3,5-dimethylbenzyl ester

There total 1 articles about N-α-boc-L-tryptophan 3,5-dimethylbenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1-bromomethyl-3,5-dimethylbenzene (27129-86-8) + Boc-Trp-OH (13139-14-5) → N-α-boc-L-tryptophan 3,5-dimethylbenzyl ester (148451-85-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; for 16h;

DOI:10.1021/jm00035a006

Reference yield: 82.5%

N-α-boc-L-tryptophan 3,5-dimethylbenzyl ester (148451-85-8) → Tryptophan 3,5-dimethylbenzyl ester hydrochloride

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 16h;

DOI:10.1021/jm00035a006

Reference yield:

N-α-boc-L-tryptophan 3,5-dimethylbenzyl ester (148451-85-8) → Tryptophan 3,5-dimethylbenzyl ester (149793-59-9)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1021/jm00066a015

upstream raw materials:

1-bromomethyl-3,5-dimethylbenzene

Boc-Trp-OH

Downstream raw materials:

Tryptophan 3,5-dimethylbenzyl ester