tert-Butyl 4-(4-ethoxyaniline)-4-(2-trimethylsilyl-1-ethynyl)-1-piperidinecarboxylate

Base Information

Chemical Name:tert-Butyl 4-(4-ethoxyaniline)-4-(2-trimethylsilyl-1-ethynyl)-1-piperidinecarboxylate
CAS No.:287736-45-2
Molecular Formula:C₂₃H₃₆N₂O₃Si
Molecular Weight:416.636
Hs Code.:

Synonyms:tert-Butyl 4-(4-ethoxyaniline)-4-(2-trimethylsilyl-1-ethynyl)-1-piperidinecarboxylate

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Chemical Property of tert-Butyl 4-(4-ethoxyaniline)-4-(2-trimethylsilyl-1-ethynyl)-1-piperidinecarboxylate

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Technology Process of tert-Butyl 4-(4-ethoxyaniline)-4-(2-trimethylsilyl-1-ethynyl)-1-piperidinecarboxylate

There total 4 articles about tert-Butyl 4-(4-ethoxyaniline)-4-(2-trimethylsilyl-1-ethynyl)-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 264253-93-2
4-(4-ethoxy-phenylimino)-piperidine-1-carboxylic acid tert-butyl ester

: 1066-54-2
trimethylsilylacetylene

: 287736-45-2
tert-Butyl 4-(4-ethoxyaniline)-4-(2-trimethylsilyl-1-ethynyl)-1-piperidinecarboxylate

Guidance literature:: trimethylsilylacetylene; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

4-(4-ethoxy-phenylimino)-piperidine-1-carboxylic acid tert-butyl ester; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/S0960-894X(00)00122-0

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 287736-45-2
tert-Butyl 4-(4-ethoxyaniline)-4-(2-trimethylsilyl-1-ethynyl)-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 33 percent / molesular sieves 5 Angstroem / diethyl ether / 20 °C

2.1: n-BuLi / tetrahydrofuran / -78 °C

2.2: 48 percent / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; 5A molecular sieve; In tetrahydrofuran; diethyl ether; 1.1: Condensation / 2.1: Metallation / 2.2: Addition;
DOI:10.1016/S0960-894X(00)00122-0

Reference yield:

: 156-43-4
4-Ethoxyaniline

: 287736-45-2
tert-Butyl 4-(4-ethoxyaniline)-4-(2-trimethylsilyl-1-ethynyl)-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 33 percent / molesular sieves 5 Angstroem / diethyl ether / 20 °C

2.1: n-BuLi / tetrahydrofuran / -78 °C

2.2: 48 percent / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; 5A molecular sieve; In tetrahydrofuran; diethyl ether; 1.1: Condensation / 2.1: Metallation / 2.2: Addition;
DOI:10.1016/S0960-894X(00)00122-0