1,3,7-trimethyl-12-propyl-10-p-tolyl-9,10-dihydro-1H-pyrimido[5',4':5,6][1,3]diazepino[2,1-f]purine-2,4,8,11(3H,6H,7H,12H)-tetraone

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Chemical Name:1,3,7-trimethyl-12-propyl-10-p-tolyl-9,10-dihydro-1H-pyrimido[5',4':5,6][1,3]diazepino[2,1-f]purine-2,4,8,11(3H,6H,7H,12H)-tetraone
CAS No.:1011405-65-4
Molecular Formula:C₂₄H₂₇N₇O₄
Molecular Weight:477.523
Hs Code.:

Synonyms:1,3,7-trimethyl-12-propyl-10-p-tolyl-9,10-dihydro-1H-pyrimido[5',4':5,6][1,3]diazepino[2,1-f]purine-2,4,8,11(3H,6H,7H,12H)-tetraone

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Chemical Property of 1,3,7-trimethyl-12-propyl-10-p-tolyl-9,10-dihydro-1H-pyrimido[5',4':5,6][1,3]diazepino[2,1-f]purine-2,4,8,11(3H,6H,7H,12H)-tetraone

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Technology Process of 1,3,7-trimethyl-12-propyl-10-p-tolyl-9,10-dihydro-1H-pyrimido[5',4':5,6][1,3]diazepino[2,1-f]purine-2,4,8,11(3H,6H,7H,12H)-tetraone

There total 4 articles about 1,3,7-trimethyl-12-propyl-10-p-tolyl-9,10-dihydro-1H-pyrimido[5',4':5,6][1,3]diazepino[2,1-f]purine-2,4,8,11(3H,6H,7H,12H)-tetraone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: ethyl 6-{[1,3-dimethyl-2,6-dioxo-8-(propylamino)-1,2,3,6-tetrahydro-7H-purin-7-yl]methyl}-1-methyl-4-(4-methylphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 1011405-65-4
1,3,7-trimethyl-12-propyl-10-p-tolyl-9,10-dihydro-1H-pyrimido[5',4':5,6][1,3]diazepino[2,1-f]purine-2,4,8,11(3H,6H,7H,12H)-tetraone

Guidance literature:: With sodium t-butanolate; In tert-butyl alcohol; for 6h; Reflux;
DOI:10.1002/ejoc.201300360

Reference yield:

: 57509-01-0
potassium salt of 8-bromo-1,3-dimethylxanthine

: 1011405-65-4
1,3,7-trimethyl-12-propyl-10-p-tolyl-9,10-dihydro-1H-pyrimido[5',4':5,6][1,3]diazepino[2,1-f]purine-2,4,8,11(3H,6H,7H,12H)-tetraone

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide; tert-butyl alcohol / 3 h / Reflux

2: tert-butyl alcohol / 8 h / Reflux

3: sodium t-butanolate / tert-butyl alcohol / 6 h / Reflux

With sodium t-butanolate; In N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/ejoc.201300360

Reference yield:

: 924851-95-6
C₁₆H₁₉BrN₂O₃

: 1011405-65-4
1,3,7-trimethyl-12-propyl-10-p-tolyl-9,10-dihydro-1H-pyrimido[5',4':5,6][1,3]diazepino[2,1-f]purine-2,4,8,11(3H,6H,7H,12H)-tetraone

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide; tert-butyl alcohol / 3 h / Reflux

2: tert-butyl alcohol / 8 h / Reflux

3: sodium t-butanolate / tert-butyl alcohol / 6 h / Reflux

With sodium t-butanolate; In N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/ejoc.201300360