methyl N-[(2S)-1-[(4-{3-[5-chloro-2-fluoro-3-(propane-1-sulfonamido)phenyl]-1-(propan-2-yl)-1H-pyrazol-4-yl}pyrimidin-2-yl)amino]propan-2-yl]carbamate

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Chemical Name:methyl N-[(2S)-1-[(4-{3-[5-chloro-2-fluoro-3-(propane-1-sulfonamido)phenyl]-1-(propan-2-yl)-1H-pyrazol-4-yl}pyrimidin-2-yl)amino]propan-2-yl]carbamate
CAS No.:1269440-09-6
Molecular Formula:C₂₄H₃₁ClFN₇O₄S
Molecular Weight:568.072
Hs Code.:

Synonyms:methyl N-[(2S)-1-[(4-{3-[5-chloro-2-fluoro-3-(propane-1-sulfonamido)phenyl]-1-(propan-2-yl)-1H-pyrazol-4-yl}pyrimidin-2-yl)amino]propan-2-yl]carbamate

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Chemical Property of methyl N-[(2S)-1-[(4-{3-[5-chloro-2-fluoro-3-(propane-1-sulfonamido)phenyl]-1-(propan-2-yl)-1H-pyrazol-4-yl}pyrimidin-2-yl)amino]propan-2-yl]carbamate

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Technology Process of methyl N-[(2S)-1-[(4-{3-[5-chloro-2-fluoro-3-(propane-1-sulfonamido)phenyl]-1-(propan-2-yl)-1H-pyrazol-4-yl}pyrimidin-2-yl)amino]propan-2-yl]carbamate

There total 18 articles about methyl N-[(2S)-1-[(4-{3-[5-chloro-2-fluoro-3-(propane-1-sulfonamido)phenyl]-1-(propan-2-yl)-1H-pyrazol-4-yl}pyrimidin-2-yl)amino]propan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10147-36-1
n-propanesulfonyl chloride

: 1269440-77-8
(S)-methyl 1-(4-(3-(5-chloro-2-fluoro-3-(tert-butoxycarbonylamino)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

: 1269440-09-6
methyl N-[(2S)-1-[(4-{3-[5-chloro-2-fluoro-3-(propane-1-sulfonamido)phenyl]-1-(propan-2-yl)-1H-pyrazol-4-yl}pyrimidin-2-yl)amino]propan-2-yl]carbamate

Guidance literature:: n-propanesulfonyl chloride; (S)-methyl 1-(4-(3-(5-chloro-2-fluoro-3-(tert-butoxycarbonylamino)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate; With triethylamine; In dichloromethane; at 20 ℃; for 16h;

With sodium carbonate; In ethanol; water; toluene; at 85 ℃; for 16h;

Reference yield:

: 89897-29-0
3-amino-1-isopropyl-1H-pyrazole-4-carbonitrile

: 1269440-09-6
methyl N-[(2S)-1-[(4-{3-[5-chloro-2-fluoro-3-(propane-1-sulfonamido)phenyl]-1-(propan-2-yl)-1H-pyrazol-4-yl}pyrimidin-2-yl)amino]propan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: tetrahydrofuran; diethyl ether / 0 °C / Reflux

1.2: pH 7

2.1: toluene-4-sulfonic acid; potassium iodide; sodium nitrite / water; acetonitrile / 0 - 20 °C

2.2: pH 9 - 10

3.1: tert-Butoxybis(dimethylamino)methane / 114 - 120 °C / Inert atmosphere

4.1: lithium hydroxide / iso-butanol / 20 h / 110 °C

5.1: trifluoroacetic acid; sodium nitrite / 0 - 20 °C

6.1: trichlorophosphate / 16 h / 110 °C

7.1: triethylamine / 1,4-dioxane; isopropyl alcohol / 48 h / 125 °C

8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 16 h / 80 °C

9.1: triethylamine / dichloromethane / 16 h / 20 °C

9.2: 16 h / 85 °C

With tert-Butoxybis(dimethylamino)methane; sodium carbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; potassium iodide; lithium hydroxide; sodium nitrite; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; isopropyl alcohol; toluene; acetonitrile; iso-butanol;

Reference yield:

: 1996-30-1
2-bromo-4-chloro-1-fluorobenzene

: 1269440-09-6
methyl N-[(2S)-1-[(4-{3-[5-chloro-2-fluoro-3-(propane-1-sulfonamido)phenyl]-1-(propan-2-yl)-1H-pyrazol-4-yl}pyrimidin-2-yl)amino]propan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

1.2: -78 - 20 °C

2.1: diphenylphosphoranyl azide; triethylamine / toluene / 2 h / 75 - 84 °C

2.2: 0.25 h / 35 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 16 h / 100 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 16 h / 80 °C

5.1: triethylamine / dichloromethane / 16 h / 20 °C

5.2: 16 h / 85 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; diphenylphosphoranyl azide; potassium acetate; sodium carbonate; triethylamine; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene;