(RS)-3-acetyl-4-(2,5-dimethoxyphenyl)-2,2-dimethyl-1-thia-3-azaspiro[4.5]decane

Base Information

Chemical Name:(RS)-3-acetyl-4-(2,5-dimethoxyphenyl)-2,2-dimethyl-1-thia-3-azaspiro[4.5]decane
CAS No.:1571129-03-7
Molecular Formula:C₂₀H₂₉NO₃S
Molecular Weight:363.521
Hs Code.:

Synonyms:(RS)-3-acetyl-4-(2,5-dimethoxyphenyl)-2,2-dimethyl-1-thia-3-azaspiro[4.5]decane

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Chemical Property of (RS)-3-acetyl-4-(2,5-dimethoxyphenyl)-2,2-dimethyl-1-thia-3-azaspiro[4.5]decane

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Technology Process of (RS)-3-acetyl-4-(2,5-dimethoxyphenyl)-2,2-dimethyl-1-thia-3-azaspiro[4.5]decane

There total 3 articles about (RS)-3-acetyl-4-(2,5-dimethoxyphenyl)-2,2-dimethyl-1-thia-3-azaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1571129-39-9
(RS)-3-acetyl-2,2-dimethyl-4-methoxy-1-thia-3-aza-spiro[4.5]decane

: 150-78-7
1,4-dimethoxybezene

: 1571129-03-7
(RS)-3-acetyl-4-(2,5-dimethoxyphenyl)-2,2-dimethyl-1-thia-3-azaspiro[4.5]decane

Guidance literature:: With aluminum (III) chloride; In dichloromethane; at 0 - 20 ℃; for 120h; Inert atmosphere; Schlenk technique;
DOI:10.1002/hc.21131

Reference yield:

: 53627-10-4
1-chlorocyclohexane-1-carbaldehyde

: 1571129-03-7
(RS)-3-acetyl-4-(2,5-dimethoxyphenyl)-2,2-dimethyl-1-thia-3-azaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogensulfide; ammonium hydroxide / dichloromethane

2.1: dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2.2: 0 - 20 °C / Inert atmosphere; Schlenk technique

3.1: aluminum (III) chloride / dichloromethane / 120 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

With aluminum (III) chloride; ammonium hydroxide; sodium hydrogensulfide; In dichloromethane; 1.1: |Asinger Thiazoline Synthesis / 3.1: |Friedel-Crafts Alkylation;
DOI:10.1002/hc.21131

Reference yield:

: 52958-72-2
2,2-dimethyl-1-thia-3-azaspiro[4.5]-dec-3-ene

: 1571129-03-7
(RS)-3-acetyl-4-(2,5-dimethoxyphenyl)-2,2-dimethyl-1-thia-3-azaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

1.2: 0 - 20 °C / Inert atmosphere; Schlenk technique

2.1: aluminum (III) chloride / dichloromethane / 120 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

With aluminum (III) chloride; In dichloromethane; 2.1: |Friedel-Crafts Alkylation;
DOI:10.1002/hc.21131