(R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)ethyl 4-methylbenzenesulfonate

Base Information

Chemical Name:(R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)ethyl 4-methylbenzenesulfonate
CAS No.:81561-74-2
Molecular Formula:C₁₆H₁₅F₃O₄S
Molecular Weight:360.354
Hs Code.:

Synonyms:(R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)ethyl 4-methylbenzenesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)ethyl 4-methylbenzenesulfonate

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Technology Process of (R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)ethyl 4-methylbenzenesulfonate

There total 3 articles about (R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)ethyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1023921-76-7
1-(3-trifluoromethylphenyl)-2-(p-tolylsulfonyloxy)ethanone

: 81561-74-2
(R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)ethyl 4-methylbenzenesulfonate

Guidance literature:: With formic acid; triethylamine hydrochloride; triethylamine; pentamethylcyclopentadienyl*RhCl[(S,S)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine]; In ethyl acetate; at 20 ℃; for 2h;

Reference yield: 44.0%

: (R)-1-(3-(trifluoromethyl)phenyl)ethane-1,2-diol

: 98-59-9
p-toluenesulfonyl chloride

: 81561-74-2
(R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)ethyl 4-methylbenzenesulfonate

Guidance literature:: With pyridine; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ja504247g

Reference yield:

: 1023921-76-7
1-(3-trifluoromethylphenyl)-2-(p-tolylsulfonyloxy)ethanone

: 81561-74-2
(R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)ethyl 4-methylbenzenesulfonate

: (S)-1-(3-trifluoromethylphenyl)-2-(p-tolylsulfonyloxy)ethanol

Guidance literature:: With formic acid; C₃₁H₃₆ClN₂O₂RhS; triethylamine; In ethyl acetate; at 20 ℃; for 2h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1007/s00706-008-0009-2