7,8-didehydro-3,6-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5-epoxy-17-methyl-(5α,6α)-morphinan

Base Information

• Chemical Name: 7,8-didehydro-3,6-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5-epoxy-17-methyl-(5α,6α)-morphinan
• CAS No.: 303175-79-3
• Molecular Formula: C₄₉H₅₅NO₃Si₂
• Molecular Weight: 762.152

Synonyms:7,8-didehydro-3,6-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5-epoxy-17-methyl-(5α,6α)-morphinan

Chemical Property of 7,8-didehydro-3,6-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5-epoxy-17-methyl-(5α,6α)-morphinan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7,8-didehydro-3,6-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5-epoxy-17-methyl-(5α,6α)-morphinan

There total 1 articles about 7,8-didehydro-3,6-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5-epoxy-17-methyl-(5α,6α)-morphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

tert-butylchlorodiphenylsilane (58479-61-1) + MORPHIN (57-27-2) → 7,8-didehydro-3,6-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5-epoxy-17-methyl-(5α,6α)-morphinan (303175-79-3)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 25 ℃; for 1h;

DOI:10.1021/jm000119i

Reference yield: 84.1%

7,8-didehydro-3,6-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5-epoxy-17-methyl-(5α,6α)-morphinan (303175-79-3) → 7,8-didehydro-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5-epoxy-17-methyl-(5α,6α)-morphinan-3-ol (303175-80-6)

Guidance literature:

With tetrabutyl ammonium fluoride; water; In tetrahydrofuran; at 25 ℃; for 1h;

DOI:10.1021/jm000119i

Reference yield: 82.0%

methyl chloroformate (79-22-1) + tert-butylchlorodiphenylsilane (58479-61-1) + 7,8-didehydro-3,6-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5-epoxy-17-methyl-(5α,6α)-morphinan (303175-79-3) → N-methyl 7,8-didehydro-3,6-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5-epoxy-(5α,6α)-morphinan carbamate

Guidance literature:

With sodium hydrogencarbonate; In chloroform; at 62 ℃; for 2.33333h; Inert atmosphere;

DOI:10.1016/j.ejmech.2018.02.074

upstream raw materials:

tert-butylchlorodiphenylsilane

MORPHIN

Downstream raw materials:

7,8-didehydro-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5-epoxy-17-methyl-(5α,6α)-morphinan-3-ol

N,N-dimethyl-7,8-didehydro-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5-epoxy-17-methyl-(5α,6α)-morphinan-3-amine

7,8-didehydro-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5-epoxy-17-methyl-(5α,6α)-morphinan-3-amine

N-methyl-7,8-didehydro-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5-epoxy-17-methyl-(5α,6α)-morphinan-3-amine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 303175-79-3 7,8-didehydro-3,6-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5-epoxy-17-methyl-(5α,6α)-morphinan

Send

Send

Metric Ton KG G Pound L ML

Send

Send