C₇₁H₁₁₉N₅O₁₅Si₂

Base Information

• Chemical Name: C₇₁H₁₁₉N₅O₁₅Si₂
• CAS No.: 383910-51-8
• Molecular Formula: C₇₁H₁₁₉N₅O₁₅Si₂
• Molecular Weight: 1338.92
• Mol file: 383910-51-8.mol

Synonyms:C₇₁H₁₁₉N₅O₁₅Si₂

Chemical Property of C₇₁H₁₁₉N₅O₁₅Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₇₁H₁₁₉N₅O₁₅Si₂

There total 7 articles about C₇₁H₁₁₉N₅O₁₅Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

(3S,4R,5S)-4-Amino-5-methyl-3-triisopropylsilanyloxy-heptanoic acid (1S,2S,3R)-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-2-methoxymethoxy-3-methyl-butyl ester (126587-57-3) + Cbz-leucylpropyl-L-(3-carboxy-1,2,3,4-tetrahydroisoquinoline)-O-Boc-threonine (383910-50-7) → C71H119N5O15Si2 (383910-51-8)

Guidance literature:

With 4-methyl-morpholine; Isopropenyl chloroformate; In dichloromethane; at -15 - 20 ℃; for 4h;

DOI:10.1021/jo0105991

Reference yield:

L-Tic-OH (74163-81-8) → C71H119N5O15Si2 (383910-51-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 97 percent / NaHCO₃ / H₂O / 1.5 h / 20 °C

2.1: 89 percent / Et₃N; DMAP; isopropenyl chloroformate / CH₂Cl₂ / 1 h / 0 °C

3.1: 86 percent / H₂ / Pd/C / methanol; ethyl acetate / 3 h / 2068.65 Torr

4.1: BOP-Cl; NMM / CH₂Cl₂ / 0.5 h / -15 °C

4.2: 60 percent / NMM / CH₂Cl₂ / 6 h / 0 °C

5.1: 100 percent / MgBr₂*Et₂O / CH₂Cl₂ / 4.5 h / -20 - 0 °C

6.1: 47 percent / NMM; isopropenyl chloroformate / CH₂Cl₂ / 4 h / -15 - 20 °C

With 4-methyl-morpholine; dmap; Isopropenyl chloroformate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydrogencarbonate; triethylamine; magnesium bromide; palladium on activated charcoal; In methanol; dichloromethane; water; ethyl acetate;

DOI:10.1021/jo0105991

Reference yield:

(S)-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-benzyl ester (79261-58-8) → C71H119N5O15Si2 (383910-51-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 89 percent / Et₃N; DMAP; isopropenyl chloroformate / CH₂Cl₂ / 1 h / 0 °C

2.1: 86 percent / H₂ / Pd/C / methanol; ethyl acetate / 3 h / 2068.65 Torr

3.1: BOP-Cl; NMM / CH₂Cl₂ / 0.5 h / -15 °C

3.2: 60 percent / NMM / CH₂Cl₂ / 6 h / 0 °C

4.1: 100 percent / MgBr₂*Et₂O / CH₂Cl₂ / 4.5 h / -20 - 0 °C

5.1: 47 percent / NMM; isopropenyl chloroformate / CH₂Cl₂ / 4 h / -15 - 20 °C

With 4-methyl-morpholine; dmap; Isopropenyl chloroformate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; magnesium bromide; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;

DOI:10.1021/jo0105991

upstream raw materials:

(3S,4R,5S)-4-Amino-5-methyl-3-triisopropylsilanyloxy-heptanoic acid (1S,2S,3R)-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-2-methoxymethoxy-3-methyl-butyl ester

Cbz-leucylpropyl-L-(3-carboxy-1,2,3,4-tetrahydroisoquinoline)-O-Boc-threonine

((benzyloxy)carbonyl)-L-leucyl-L-proline

L-Tic-OH

Downstream raw materials:

C₆₅H₁₀₃O₁₅N₅SiO

C₇₁H₁₀₂F₅N₅O₁₆Si

C₆₅H₁₀₅N₅O₁₅Si