Technology Process of (3aS,6S,6aS)-2,2,6-Trimethyl-6-p-tolyl-tetrahydro-cyclopenta[1,3]dioxol-4-one
There total 10 articles about (3aS,6S,6aS)-2,2,6-Trimethyl-6-p-tolyl-tetrahydro-cyclopenta[1,3]dioxol-4-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3aS,6aS)-2,2,6-Trimethyl-3a,6a-dihydro-cyclopenta[1,3]dioxol-4-one; para-methylphenylmagnesium bromide;
With
N,N,N,N,N,N-hexamethylphosphoric triamide; chloro-trimethyl-silane; copper(I) bromide dimethylsulfide complex;
In
tetrahydrofuran;
at -78 ℃;
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
DOI:10.1016/S0040-4039(00)00235-5
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 95 percent / imidazole / dimethylformamide
2.1: 90 percent / NMO / OsO4 / H2O; tetrahydrofuran
3.1: 99 percent / PPTS / CH2Cl2
4.1: 96 percent / H2 / Pd-C; CHCl3 / ethyl acetate
5.1: 97 percent
6.1: 88 percent / CeCl3 / tetrahydrofuran / -78 °C
7.1: 88 percent / TBAF / tetrahydrofuran
8.1: 90 percent / PCC / CH2Cl2
9.1: 93 percent / acetic acid / 40 °C
10.1: CuBr*SMe2; HMPA; TMSCl / tetrahydrofuran / -78 °C
10.2: 87 percent / TBAF / tetrahydrofuran
With
1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; chloro-trimethyl-silane; N-methyl-2-indolinone; cerium(III) chloride; copper(I) bromide dimethylsulfide complex; tetrabutyl ammonium fluoride; hydrogen; pyridinium chlorochromate;
palladium on activated charcoal; osmium(VIII) oxide; chloroform; pyridinium p-toluenesulfonate;
In
tetrahydrofuran; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
1.1: Silylation / 2.1: Oxidation / 3.1: Acetalization / 4.1: Hydrogenolysis / 5.1: Oxidation / 6.1: Methylation / 7.1: Desilylation / 8.1: Oxidation / 9.1: Dehydration / 10.1: Grignard reaction / 10.2: Desilylation;
DOI:10.1016/S0040-4039(00)00235-5
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 90 percent / NMO / OsO4 / H2O; tetrahydrofuran
2.1: 99 percent / PPTS / CH2Cl2
3.1: 96 percent / H2 / Pd-C; CHCl3 / ethyl acetate
4.1: 97 percent
5.1: 88 percent / CeCl3 / tetrahydrofuran / -78 °C
6.1: 88 percent / TBAF / tetrahydrofuran
7.1: 90 percent / PCC / CH2Cl2
8.1: 93 percent / acetic acid / 40 °C
9.1: CuBr*SMe2; HMPA; TMSCl / tetrahydrofuran / -78 °C
9.2: 87 percent / TBAF / tetrahydrofuran
With
N,N,N,N,N,N-hexamethylphosphoric triamide; chloro-trimethyl-silane; N-methyl-2-indolinone; cerium(III) chloride; copper(I) bromide dimethylsulfide complex; tetrabutyl ammonium fluoride; hydrogen; pyridinium chlorochromate;
palladium on activated charcoal; osmium(VIII) oxide; chloroform; pyridinium p-toluenesulfonate;
In
tetrahydrofuran; dichloromethane; water; acetic acid; ethyl acetate;
1.1: Oxidation / 2.1: Acetalization / 3.1: Hydrogenolysis / 4.1: Oxidation / 5.1: Methylation / 6.1: Desilylation / 7.1: Oxidation / 8.1: Dehydration / 9.1: Grignard reaction / 9.2: Desilylation;
DOI:10.1016/S0040-4039(00)00235-5
![(3aS,6aS)-2,2,6-Trimethyl-3a,6a-dihydro-cyclopenta[1,3]dioxol-4-one](/Databaselist/images/loading.webp)
