Acetic acid (2S,3S,4R,5R,6S)-4,5-diacetoxy-2-[(1R,2R)-2-(3-bromomethyl-phenyl)-2-hydroxy-cyclohexyloxy]-6-methyl-tetrahydro-pyran-3-yl ester

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Chemical Name:Acetic acid (2S,3S,4R,5R,6S)-4,5-diacetoxy-2-[(1R,2R)-2-(3-bromomethyl-phenyl)-2-hydroxy-cyclohexyloxy]-6-methyl-tetrahydro-pyran-3-yl ester
CAS No.:206053-71-6
Molecular Formula:C₂₅H₃₃BrO₉
Molecular Weight:557.436
Hs Code.:

Synonyms:Acetic acid (2S,3S,4R,5R,6S)-4,5-diacetoxy-2-[(1R,2R)-2-(3-bromomethyl-phenyl)-2-hydroxy-cyclohexyloxy]-6-methyl-tetrahydro-pyran-3-yl ester

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Chemical Property of Acetic acid (2S,3S,4R,5R,6S)-4,5-diacetoxy-2-[(1R,2R)-2-(3-bromomethyl-phenyl)-2-hydroxy-cyclohexyloxy]-6-methyl-tetrahydro-pyran-3-yl ester

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Technology Process of Acetic acid (2S,3S,4R,5R,6S)-4,5-diacetoxy-2-[(1R,2R)-2-(3-bromomethyl-phenyl)-2-hydroxy-cyclohexyloxy]-6-methyl-tetrahydro-pyran-3-yl ester

There total 5 articles about Acetic acid (2S,3S,4R,5R,6S)-4,5-diacetoxy-2-[(1R,2R)-2-(3-bromomethyl-phenyl)-2-hydroxy-cyclohexyloxy]-6-methyl-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 206053-70-5
Acetic acid (2S,3S,4R,5R,6S)-4,5-diacetoxy-2-((1R,2R)-2-hydroxy-2-m-tolyl-cyclohexyloxy)-6-methyl-tetrahydro-pyran-3-yl ester

: 206053-71-6
Acetic acid (2S,3S,4R,5R,6S)-4,5-diacetoxy-2-[(1R,2R)-2-(3-bromomethyl-phenyl)-2-hydroxy-cyclohexyloxy]-6-methyl-tetrahydro-pyran-3-yl ester

: Acetic acid (2S,3S,4R,5R,6S)-4,5-diacetoxy-2-[(1R,2R)-2-(3-dibromomethyl-phenyl)-2-hydroxy-cyclohexyloxy]-6-methyl-tetrahydro-pyran-3-yl ester

Guidance literature:: With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 1h; Heating;
DOI:10.1016/S0040-4020(98)00105-7

Reference yield:

: 22618-50-4
3'-methyl-2,3,4,5-tetrahydro-1,1'-biphenyl

: 206053-71-6
Acetic acid (2S,3S,4R,5R,6S)-4,5-diacetoxy-2-[(1R,2R)-2-(3-bromomethyl-phenyl)-2-hydroxy-cyclohexyloxy]-6-methyl-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / AD-Mix-β, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 17 h / 0 °C

2: 76 percent / 4A MS, TMS-OTf / diethyl ether / 6 h / 20 °C

3: H₂ / 10percent Pd/C / methanol / 12 h / 20 °C

4: DMAP / CH₂Cl₂; pyridine / 12 h / 20 °C

5: 97 percent / NBS, AIBN / CCl₄ / 1 h / Heating

With dmap; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); methanesulfonamide; trimethylsilyl trifluoromethanesulfonate; AD-mix-β; hydrogen; palladium on activated charcoal; In pyridine; methanol; tetrachloromethane; diethyl ether; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(98)00105-7

Reference yield:

: 93429-68-6
(1R,2R)-1-(3-methylphenyl)cyclohexane-1,2-diol

: 206053-71-6
Acetic acid (2S,3S,4R,5R,6S)-4,5-diacetoxy-2-[(1R,2R)-2-(3-bromomethyl-phenyl)-2-hydroxy-cyclohexyloxy]-6-methyl-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / 4A MS, TMS-OTf / diethyl ether / 6 h / 20 °C

2: H₂ / 10percent Pd/C / methanol / 12 h / 20 °C

3: DMAP / CH₂Cl₂; pyridine / 12 h / 20 °C

4: 97 percent / NBS, AIBN / CCl₄ / 1 h / Heating

With dmap; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; hydrogen; palladium on activated charcoal; In pyridine; methanol; tetrachloromethane; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4020(98)00105-7