1-(4-{1-[2-(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-3-methyl-urea

Base Information

• Chemical Name: 1-(4-{1-[2-(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-3-methyl-urea
• CAS No.: 1076690-50-0
• Molecular Formula: C₂₁H₂₃BrN₄O₄
• Molecular Weight: 475.342
• Mol file: 1076690-50-0.mol

Synonyms:1-(4-{1-[2-(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-3-methyl-urea

Chemical Property of 1-(4-{1-[2-(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-3-methyl-urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-{1-[2-(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-3-methyl-urea

There total 5 articles about 1-(4-{1-[2-(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-3-methyl-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

1-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-3-methyl-urea (1076690-84-0) + 6-bromohomoveratric acid (4697-62-5) → 1-(4-{1-[2-(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-3-methyl-urea (1076690-50-0)

Guidance literature:

6-bromohomoveratric acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃;

1-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-3-methyl-urea; In tetrahydrofuran; at 20 ℃; for 0.166667h;

With triethylamine; In tetrahydrofuran; at 20 ℃; for 1.5h;

Reference yield:

3-(4-amino-phenyl)-4,5-dihydro-pyrazole-1-carboxylic acid tert-butyl ester (1076690-82-8) → 1-(4-{1-[2-(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-3-methyl-urea (1076690-50-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetonitrile / 18 h / 85 °C

2.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C

3.2: 0.17 h / 20 °C

3.3: 1.5 h / 20 °C

With oxalyl dichloride; trifluoroacetic acid; N,N-dimethyl-formamide; In dichloromethane; acetonitrile;

Reference yield:

3-[4-(3-methyl-ureido)-phenyl]-4,5-dihydro-pyrazole-1-carboxylic acid tert-butyl ester (1076690-83-9) → 1-(4-{1-[2-(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-3-methyl-urea (1076690-50-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C

2.2: 0.17 h / 20 °C

2.3: 1.5 h / 20 °C

With oxalyl dichloride; trifluoroacetic acid; N,N-dimethyl-formamide; In dichloromethane;

upstream raw materials:

1-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-3-methyl-urea

6-bromohomoveratric acid

3-(4-amino-phenyl)-4,5-dihydro-pyrazole-1-carboxylic acid tert-butyl ester

3-(4-nitro-phenyl)-4,5-dihydro-pyrazole-1-carboxylic acid tert-butyl ester

Downstream raw materials:

1-(4-{1-[2-(4,5-dimethoxy-biphenyl-2-yl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-3-methyl-urea