2-butyl-6-chloro-4,5-dimethyl-3-<(2'-cyanobiphenyl-4-yl)methyl>-pyridine-N-oxide

Base Information

Chemical Name:2-butyl-6-chloro-4,5-dimethyl-3-<(2'-cyanobiphenyl-4-yl)methyl>-pyridine-N-oxide
CAS No.:168072-29-5
Molecular Formula:C₂₅H₂₅ClN₂O
Molecular Weight:404.939
Hs Code.:

Synonyms:2-butyl-6-chloro-4,5-dimethyl-3-<(2'-cyanobiphenyl-4-yl)methyl>-pyridine-N-oxide

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Chemical Property of 2-butyl-6-chloro-4,5-dimethyl-3-<(2'-cyanobiphenyl-4-yl)methyl>-pyridine-N-oxide

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Technology Process of 2-butyl-6-chloro-4,5-dimethyl-3-<(2'-cyanobiphenyl-4-yl)methyl>-pyridine-N-oxide

There total 16 articles about 2-butyl-6-chloro-4,5-dimethyl-3-<(2'-cyanobiphenyl-4-yl)methyl>-pyridine-N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.7%

: 4'-(2-Butyl-6-chloro-4,5-dimethyl-pyridin-3-ylmethyl)-biphenyl-2-carbonitrile

: 168072-29-5
2-butyl-6-chloro-4,5-dimethyl-3-<(2'-cyanobiphenyl-4-yl)methyl>-pyridine-N-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In chloroform; for 4h; Ambient temperature;
DOI:10.1248/cpb.42.1841

Reference yield:

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 168072-29-5
2-butyl-6-chloro-4,5-dimethyl-3-<(2'-cyanobiphenyl-4-yl)methyl>-pyridine-N-oxide

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Mg / 1.) THF, 20 deg C, 2.) THF, 20 deg C, 2 h

2: 1.) Mg / 1.) THF, 2.) THF, -78 deg C, 1.5 h

3: SOCl₂ / 0.5 h / 60 °C

4: Zn, AcOH / 0.58 h / Ambient temperature

5: 93.1 percent / POCl₃, pyridine / 3 h / 100 °C

6: 73.7 percent / m-chloroperoxybenzoic acid / CHCl₃ / 4 h / Ambient temperature

With pyridine; thionyl chloride; magnesium; acetic acid; 3-chloro-benzenecarboperoxoic acid; zinc; trichlorophosphate; In chloroform;
DOI:10.1248/cpb.42.1841

Reference yield:

: 1115-11-3
2-methyl-2-pentenal

: 168072-29-5
2-butyl-6-chloro-4,5-dimethyl-3-<(2'-cyanobiphenyl-4-yl)methyl>-pyridine-N-oxide

Guidance literature:: Multi-step reaction with 11 steps

1: piperidine / ethanol / 3 h / Heating

2: 1 N aq. (NH₄)2Ce(NO₃)6 / acetone / 0.33 h / 0 °C

3: 98.3 percent / m-chloroperoxybenzoic acid / CHCl₃ / 4 h / Ambient temperature

4: POCl₃ / 2 h / Heating

5: LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

6: MnO₂ / CHCl₃ / 5 h / Heating

7: 1.) Mg / 1.) THF, 2.) THF, -78 deg C, 1.5 h

8: SOCl₂ / 0.5 h / 60 °C

9: Zn, AcOH / 0.58 h / Ambient temperature

10: 93.1 percent / POCl₃, pyridine / 3 h / 100 °C

11: 73.7 percent / m-chloroperoxybenzoic acid / CHCl₃ / 4 h / Ambient temperature

With piperidine; pyridine; manganese(IV) oxide; lithium aluminium tetrahydride; thionyl chloride; ammonium cerium(IV) nitrate; magnesium; acetic acid; 3-chloro-benzenecarboperoxoic acid; zinc; trichlorophosphate; In tetrahydrofuran; ethanol; chloroform; acetone;
DOI:10.1248/cpb.42.1841