N₁-(tert-butoxycarbonyl)-2-bromo-3-(2-(p-toluenesulfonylamido)ethyl)indole

Base Information

• Chemical Name: N₁-(tert-butoxycarbonyl)-2-bromo-3-(2-(p-toluenesulfonylamido)ethyl)indole
• CAS No.: 1214998-42-1
• Molecular Formula: C₂₂H₂₅BrN₂O₄S
• Molecular Weight: 493.421
• Mol file: 1214998-42-1.mol

Synonyms:N₁-(tert-butoxycarbonyl)-2-bromo-3-(2-(p-toluenesulfonylamido)ethyl)indole

Chemical Property of N₁-(tert-butoxycarbonyl)-2-bromo-3-(2-(p-toluenesulfonylamido)ethyl)indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-(tert-butoxycarbonyl)-2-bromo-3-(2-(p-toluenesulfonylamido)ethyl)indole

There total 1 articles about N₁-(tert-butoxycarbonyl)-2-bromo-3-(2-(p-toluenesulfonylamido)ethyl)indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-bromo-3-(2-(p-toluenesulfonylamido)ethyl)indole + di-tert-butyl dicarbonate (24424-99-5) → N1-(tert-butoxycarbonyl)-2-bromo-3-(2-(p-toluenesulfonylamido)ethyl)indole (1214998-42-1)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jo902652h

Reference yield: 83.0%

acrylic acid n-butyl ester (141-32-2,9003-49-0) + N1-(tert-butoxycarbonyl)-2-bromo-3-(2-(p-toluenesulfonylamido)ethyl)indole (1214998-42-1) → butyl 2-(9-tert-butoxycarbonyl-2-(p-toluenesulfonyl)-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)acetate (1214998-46-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In toluene; at 120 ℃; for 16h;

DOI:10.1021/jo902652h

Reference yield: 80.0%

N1-(tert-butoxycarbonyl)-2-bromo-3-(2-(p-toluenesulfonylamido)ethyl)indole (1214998-42-1) + 2-propenamide (79-06-1,12624-24-7,25038-45-3,27754-57-0,33338-03-3,39387-77-4,68247-81-4,9082-06-8,79079-15-5) → 2-(9-tert-butoxycarbonyl-2-(p-toluenesulfonyl)-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)acetamide (1214998-53-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In toluene; at 120 ℃; for 16h; Inert atmosphere;

DOI:10.1039/c0ob00835d

upstream raw materials:

di-tert-butyl dicarbonate

Downstream raw materials:

butyl 2-(9-tert-butoxycarbonyl-2-(p-toluenesulfonyl)-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)acetate

2-(9-tertbutoxycarbonyl-2-(p-toluenesulfonyl)-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)acrylonitrile

C₂₀H₂₁N₃O₃S

2-(9-tert-butoxycarbonyl-2-(p-toluenesulfonyl)-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)acetamide