5-(3-fluoro-phenylethynyl)-pyridine-2-carboxylic acid tert-butyl-ethyl-amide

Base Information

Chemical Name:5-(3-fluoro-phenylethynyl)-pyridine-2-carboxylic acid tert-butyl-ethyl-amide
CAS No.:1602491-38-2
Molecular Formula:C₂₀H₂₁FN₂O
Molecular Weight:324.398
Hs Code.:

Synonyms:5-(3-fluoro-phenylethynyl)-pyridine-2-carboxylic acid tert-butyl-ethyl-amide

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Chemical Property of 5-(3-fluoro-phenylethynyl)-pyridine-2-carboxylic acid tert-butyl-ethyl-amide

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Technology Process of 5-(3-fluoro-phenylethynyl)-pyridine-2-carboxylic acid tert-butyl-ethyl-amide

There total 3 articles about 5-(3-fluoro-phenylethynyl)-pyridine-2-carboxylic acid tert-butyl-ethyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 4432-77-3
N-t-butylethylamine

: 1403771-21-0
5-(3-fluoro-phenylethynyl)-pyridine-2-carboxylic acid

: 1602491-38-2
5-(3-fluoro-phenylethynyl)-pyridine-2-carboxylic acid tert-butyl-ethyl-amide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 20 ℃; for 16h;

Reference yield:

: 29682-15-3
methyl 5-bromopicolinate

: 1602491-38-2
5-(3-fluoro-phenylethynyl)-pyridine-2-carboxylic acid tert-butyl-ethyl-amide

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 20 h / 20 - 80 °C

2: lithium hydroxide; water / tetrahydrofuran / 16 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 1,4-dioxane / 16 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 2561-17-3
1-ethynyl-3-fluoro-benzene

: 1602491-38-2
5-(3-fluoro-phenylethynyl)-pyridine-2-carboxylic acid tert-butyl-ethyl-amide

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 20 h / 20 - 80 °C

2: lithium hydroxide; water / tetrahydrofuran / 16 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 1,4-dioxane / 16 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;