(3R,4S)-methyl-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylate

Base Information

Chemical Name:(3R,4S)-methyl-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylate
CAS No.:297748-84-6
Molecular Formula:C₂₀H₂₀FNO₃
Molecular Weight:341.382
Hs Code.:

Synonyms:(3R,4S)-methyl-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylate

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Chemical Property of (3R,4S)-methyl-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylate

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Technology Process of (3R,4S)-methyl-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylate

There total 12 articles about (3R,4S)-methyl-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 616-38-6
carbonic acid dimethyl ester

: 177966-75-5
(4S)-1-(phenylmethyl)-4-(4-fluorophenyl)piperidin-2-one

: 297748-84-6
(3R,4S)-methyl-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylate

Guidance literature:: With sodium methylate; sodium hydride; In toluene; Heating;
DOI:10.1016/S0040-4039(00)00942-4

Reference yield:

: methyl 1-benzyl-4-(4-fluorophenyl)-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxylate

: methyl 1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylate

: 297748-84-6
(3R,4S)-methyl-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylate

Guidance literature:: With bis(norbornadiene)rhodium(l)tetrafluoroborate; (R)-1-{((S)-2-di-(4-methoxy-3,5-dimethylphenyl)phosphino)ferrocenyl}ethyldicyclohexylphosphine; hydrogen; In toluene; at 40 ℃; for 72h; under 60006 Torr; Overall yield = 96 percent; Overall yield = 16.1 mg; stereoselective reaction; Autoclave;
DOI:10.1021/acs.orglett.1c04132

Reference yield:

: C₂₀H₂₀FNO₄

: methyl 1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylate

: 297748-84-6
(3R,4S)-methyl-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluorormethanesulfonic acid / dichloromethane / 24 h / 45 °C / Inert atmosphere

2: bis(norbornadiene)rhodium(l)tetrafluoroborate; hydrogen; (R)-1-{((S)-2-di-(4-methoxy-3,5-dimethylphenyl)phosphino)ferrocenyl}ethyldicyclohexylphosphine / toluene / 72 h / 40 °C / 60006 Torr / Autoclave

With bis(norbornadiene)rhodium(l)tetrafluoroborate; trifluorormethanesulfonic acid; (R)-1-{((S)-2-di-(4-methoxy-3,5-dimethylphenyl)phosphino)ferrocenyl}ethyldicyclohexylphosphine; hydrogen; In dichloromethane; toluene;
DOI:10.1021/acs.orglett.1c04132