(S)-1-((S)-1-cyclohexyl-3-phenylprop-2-yn-1-yl)-2-(pyrrolidin-1-ylmethyl)pyrrolidine

Base Information

Chemical Name:(S)-1-((S)-1-cyclohexyl-3-phenylprop-2-yn-1-yl)-2-(pyrrolidin-1-ylmethyl)pyrrolidine
CAS No.:1422177-18-1
Molecular Formula:C₂₄H₃₄N₂
Molecular Weight:350.547
Hs Code.:

Synonyms:(S)-1-((S)-1-cyclohexyl-3-phenylprop-2-yn-1-yl)-2-(pyrrolidin-1-ylmethyl)pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-((S)-1-cyclohexyl-3-phenylprop-2-yn-1-yl)-2-(pyrrolidin-1-ylmethyl)pyrrolidine

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Technology Process of (S)-1-((S)-1-cyclohexyl-3-phenylprop-2-yn-1-yl)-2-(pyrrolidin-1-ylmethyl)pyrrolidine

There total 2 articles about (S)-1-((S)-1-cyclohexyl-3-phenylprop-2-yn-1-yl)-2-(pyrrolidin-1-ylmethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 51207-66-0
(S)-2-(1-pyrrolidinylmethyl)pyrrolidine

: 536-74-3
phenylacetylene

: 2043-61-0
cyclohexanecarbaldehyde

: 1422177-18-1
(S)-1-((S)-1-cyclohexyl-3-phenylprop-2-yn-1-yl)-2-(pyrrolidin-1-ylmethyl)pyrrolidine

Guidance literature:: With copper(I) bromide; In toluene; at 25 ℃; for 36h; diastereoselective reaction; Molecular sieve;
DOI:10.1021/jo302534f

Reference yield:

: 1422177-07-8
(S)-1-((S)-1-phenylundec-2-yn-1-yl)-2-(pyrrolidin-1-ylmethyl)-pyrrolidine

: 1422177-18-1
(S)-1-((S)-1-cyclohexyl-3-phenylprop-2-yn-1-yl)-2-(pyrrolidin-1-ylmethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere

1.2: 2 h / 0 - 25 °C

2.1: copper(I) bromide / toluene / 36 h / 25 °C / Molecular sieve

With copper(l) iodide; copper(I) bromide; In 1,4-dioxane; toluene;
DOI:10.1021/jo302534f

Reference yield: 65.0%

: 1422177-18-1
(S)-1-((S)-1-cyclohexyl-3-phenylprop-2-yn-1-yl)-2-(pyrrolidin-1-ylmethyl)pyrrolidine

: 67647-93-2
(R)-(3-cyclohexylpropa-1,2-dien-1-yl)benzene

: 1422177-45-4
C₉H₁₆N₂

Guidance literature:: With copper(l) iodide; In 1,4-dioxane; at 100 ℃; for 18h; enantioselective reaction; Inert atmosphere;
DOI:10.1021/jo302534f