(E)-methyl 4-{2-fluoro-4-[3-(4-nitrophenyl)acrylamido]phenyl}piperazine-1-carboxylate

Base Information

Chemical Name:(E)-methyl 4-{2-fluoro-4-[3-(4-nitrophenyl)acrylamido]phenyl}piperazine-1-carboxylate
CAS No.:1580002-88-5
Molecular Formula:C₂₁H₂₁FN₄O₅
Molecular Weight:428.42
Hs Code.:

Synonyms:(E)-methyl 4-{2-fluoro-4-[3-(4-nitrophenyl)acrylamido]phenyl}piperazine-1-carboxylate

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Chemical Property of (E)-methyl 4-{2-fluoro-4-[3-(4-nitrophenyl)acrylamido]phenyl}piperazine-1-carboxylate

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Technology Process of (E)-methyl 4-{2-fluoro-4-[3-(4-nitrophenyl)acrylamido]phenyl}piperazine-1-carboxylate

There total 7 articles about (E)-methyl 4-{2-fluoro-4-[3-(4-nitrophenyl)acrylamido]phenyl}piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.85%

: 1580002-77-2
(E)-N-[3-fluoro-4-(piperazin-1-yl)phenyl]-3-(4-nitrophenyl)acrylamide

: 79-22-1
methyl chloroformate

: 1580002-88-5
(E)-methyl 4-{2-fluoro-4-[3-(4-nitrophenyl)acrylamido]phenyl}piperazine-1-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.01.024

Reference yield:

: 1580002-73-8
(E)-tert-butyl 4-{2-fluoro-4-[3-(4-nitrophenyl)acrylamido]phenyl}piperazine-1-carboxylate

: 1580002-88-5
(E)-methyl 4-{2-fluoro-4-[3-(4-nitrophenyl)acrylamido]phenyl}piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

1.2: 0.17 h

2.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.ejmech.2014.01.024

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 1580002-88-5
(E)-methyl 4-{2-fluoro-4-[3-(4-nitrophenyl)acrylamido]phenyl}piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / dimethyl sulfoxide / 12 h / 90 °C

2.1: hydrogen; palladium 10% on activated carbon / ethyl acetate; methanol / 6 h / 5171.62 Torr

3.1: pyridine / dichloromethane / 3 h / 0 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

4.2: 0.17 h

5.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;
DOI:10.1016/j.ejmech.2014.01.024