benzyloxycarbonyl D-alanyl L-α-hydroxyhydrocinnamyl L-valyl D-α-hydroxy hydrocinnamic acid pentafluorophenyl ester

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Chemical Name:benzyloxycarbonyl D-alanyl L-α-hydroxyhydrocinnamyl L-valyl D-α-hydroxy hydrocinnamic acid pentafluorophenyl ester
CAS No.:174538-94-4
Molecular Formula:C₄₀H₃₇F₅N₂O₉
Molecular Weight:784.734
Hs Code.:

Synonyms:benzyloxycarbonyl D-alanyl L-α-hydroxyhydrocinnamyl L-valyl D-α-hydroxy hydrocinnamic acid pentafluorophenyl ester

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Chemical Property of benzyloxycarbonyl D-alanyl L-α-hydroxyhydrocinnamyl L-valyl D-α-hydroxy hydrocinnamic acid pentafluorophenyl ester

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Technology Process of benzyloxycarbonyl D-alanyl L-α-hydroxyhydrocinnamyl L-valyl D-α-hydroxy hydrocinnamic acid pentafluorophenyl ester

There total 10 articles about benzyloxycarbonyl D-alanyl L-α-hydroxyhydrocinnamyl L-valyl D-α-hydroxy hydrocinnamic acid pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 174538-93-3
benzyloxycarbonyl D-alanyl L-α-hydroxyhydrocinnamyl L-valyl D-α-hydroxy hydrocinnamic acid

: 174538-94-4
benzyloxycarbonyl D-alanyl L-α-hydroxyhydrocinnamyl L-valyl D-α-hydroxy hydrocinnamic acid pentafluorophenyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 24h;
DOI:10.1016/0040-4020(95)00964-7

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 174538-94-4
benzyloxycarbonyl D-alanyl L-α-hydroxyhydrocinnamyl L-valyl D-α-hydroxy hydrocinnamic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / dimethylaminopyridine, DCC / CH₂Cl₂ / 24 h / Ambient temperature

2: 100 percent / H₂ / 10percent Pd/C / ethanol / 12 h

3: 92 percent / dimethylaminopyridine, DCC / CH₂Cl₂ / 12 h / 0 °C

4: 100 percent / TFA / CH₂Cl₂ / 5 h / Ambient temperature

5: 76 percent / DCC / CH₂Cl₂ / 24 h / 0 °C

With dmap; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/0040-4020(95)00964-7

Reference yield:

: 111505-52-3
D-α-hydroxyhydrocinnamic acid t-butyl ester

: 174538-94-4
benzyloxycarbonyl D-alanyl L-α-hydroxyhydrocinnamyl L-valyl D-α-hydroxy hydrocinnamic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / dimethylaminopyridine, DCC / CH₂Cl₂ / 24 h / Ambient temperature

2: 100 percent / H₂ / 10percent Pd/C / ethanol / 12 h

3: 92 percent / dimethylaminopyridine, DCC / CH₂Cl₂ / 12 h / 0 °C

4: 100 percent / TFA / CH₂Cl₂ / 5 h / Ambient temperature

5: 76 percent / DCC / CH₂Cl₂ / 24 h / 0 °C

With dmap; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/0040-4020(95)00964-7