1-(4-chloro-phenyl)-2-{[2-(1H-indol-3-yl)-ethyl]-methyl-amino}-ethanone

Base Information

Chemical Name:1-(4-chloro-phenyl)-2-{[2-(1H-indol-3-yl)-ethyl]-methyl-amino}-ethanone
CAS No.:760957-18-4
Molecular Formula:C₁₉H₁₉ClN₂O
Molecular Weight:326.826
Hs Code.:

1-(4-chloro-phenyl)-2-{[2-(1<i>H</i>-indol-3-yl)-ethyl]-methyl-amino}-ethanone

Synonyms:1-(4-chloro-phenyl)-2-{[2-(1H-indol-3-yl)-ethyl]-methyl-amino}-ethanone

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Chemical Property of 1-(4-chloro-phenyl)-2-{[2-(1H-indol-3-yl)-ethyl]-methyl-amino}-ethanone

Chemical Property:

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Technology Process of 1-(4-chloro-phenyl)-2-{[2-(1H-indol-3-yl)-ethyl]-methyl-amino}-ethanone

There total 4 articles about 1-(4-chloro-phenyl)-2-{[2-(1H-indol-3-yl)-ethyl]-methyl-amino}-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 61-49-4
[2-(1H-indol-3-yl)-ethyl]-methylamine

: 536-38-9
4-chlorobenzoylmethyl bromide

: 760957-18-4
1-(4-chloro-phenyl)-2-{[2-(1H-indol-3-yl)-ethyl]-methyl-amino}-ethanone

Guidance literature:: With sodium hydrogencarbonate; sodium sulfite; In toluene; at 20 ℃; for 4h;
DOI:10.1039/b518019h

Reference yield:

: 67909-99-3
ethyl 2-(1H-indole-3-yl)ethylcarbamate

: 760957-18-4
1-(4-chloro-phenyl)-2-{[2-(1H-indol-3-yl)-ethyl]-methyl-amino}-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / LiAlH₄ / tetrahydrofuran / 1 h / Heating

2: 61 percent / aq. NaHCO₃; Na₂SO₃ / toluene / 4 h / 20 °C

With lithium aluminium tetrahydride; sodium hydrogencarbonate; sodium sulfite; In tetrahydrofuran; toluene;
DOI:10.1039/b518019h

Reference yield:

: 61-54-1
tryptamine

: 760957-18-4
1-(4-chloro-phenyl)-2-{[2-(1H-indol-3-yl)-ethyl]-methyl-amino}-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / aq. NaOH / CHCl₃ / 3 h

2: 89 percent / LiAlH₄ / tetrahydrofuran / 1 h / Heating

3: aq. NaHCO₃; Na₂SO₄ / toluene / 4 h

With sodium hydroxide; lithium aluminium tetrahydride; sodium hydrogencarbonate; sodium sulfate; In tetrahydrofuran; chloroform; toluene;
DOI:10.1039/b406076h