Technology Process of dibenzyl Nα-tert-carbobenzyloxy-Nα'-benzyl-τ-L-histidino-D-alaninate
There total 6 articles about dibenzyl Nα-tert-carbobenzyloxy-Nα'-benzyl-τ-L-histidino-D-alaninate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Nα-(carbobenzyloxy)histidine benzyl ester; benzyl 4R,3-Benzyl-2,2-dioxo-1,2,3-oxathiazolidine-4-carboxylate;
In
1,2-dimethoxyethane;
at 80 ℃;
for 5h;
With
potassium dihydrogenphosphate; water;
at 20 ℃;
DOI:10.1021/jo200744d
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine; thionyl chloride / dichloromethane / 2.25 h / -78 - 20 °C
2.1: sodium periodate; ruthenium(III) chloride trihydrate / water; acetonitrile / 0.67 h / -5 - 20 °C
3.1: 1,2-dimethoxyethane / 5 h / 80 °C
3.2: 20 °C
With
pyridine; sodium periodate; thionyl chloride; ruthenium(III) chloride trihydrate;
In
1,2-dimethoxyethane; dichloromethane; water; acetonitrile;
DOI:10.1021/jo200744d
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate / methanol / 4 h / 0 °C
2.1: pyridine; thionyl chloride / dichloromethane / 2.25 h / -78 - 20 °C
3.1: sodium periodate; ruthenium(III) chloride trihydrate / water; acetonitrile / 0.67 h / -5 - 20 °C
4.1: 1,2-dimethoxyethane / 5 h / 80 °C
4.2: 20 °C
With
pyridine; sodium tetrahydroborate; sodium periodate; thionyl chloride; ruthenium(III) chloride trihydrate;
In
methanol; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile;
DOI:10.1021/jo200744d
