tert-butyl 1-(3-(2-cyanoquinolin-6-yloxy)propylamino)-1-oxo-3-(tritylthio)propan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl 1-(3-(2-cyanoquinolin-6-yloxy)propylamino)-1-oxo-3-(tritylthio)propan-2-ylcarbamate
CAS No.:1289513-16-1
Molecular Formula:C₄₀H₄₀N₄O₄S
Molecular Weight:672.848
Hs Code.:

Synonyms:tert-butyl 1-(3-(2-cyanoquinolin-6-yloxy)propylamino)-1-oxo-3-(tritylthio)propan-2-ylcarbamate

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Chemical Property of tert-butyl 1-(3-(2-cyanoquinolin-6-yloxy)propylamino)-1-oxo-3-(tritylthio)propan-2-ylcarbamate

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Technology Process of tert-butyl 1-(3-(2-cyanoquinolin-6-yloxy)propylamino)-1-oxo-3-(tritylthio)propan-2-ylcarbamate

There total 3 articles about tert-butyl 1-(3-(2-cyanoquinolin-6-yloxy)propylamino)-1-oxo-3-(tritylthio)propan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 6-(3-aminopropoxy)quinoline-2-carbonitrile trifluoroacetate

: 21947-98-8,87494-13-1
N-tert-butyloxycarbonyl-S-trityl-L-cysteine

: 1289513-16-1
tert-butyl 1-(3-(2-cyanoquinolin-6-yloxy)propylamino)-1-oxo-3-(tritylthio)propan-2-ylcarbamate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1002/anie.201006140

Reference yield:

: 916660-64-5
tert-butyl 3-(2-cyanoquinolin-6-yloxy)propylcarbamate

: 1289513-16-1
tert-butyl 1-(3-(2-cyanoquinolin-6-yloxy)propylamino)-1-oxo-3-(tritylthio)propan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 2 h

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201006140

Reference yield:

: 5467-79-8
2-cyano-6-methoxyquinoline

: 1289513-16-1
tert-butyl 1-(3-(2-cyanoquinolin-6-yloxy)propylamino)-1-oxo-3-(tritylthio)propan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 80 °C

2: dichloromethane / 2 h

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; potassium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201006140